ASSISTANT PROFESSOR 55.2025

Job title:

ASSISTANT PROFESSOR 55.2025

Company:

Job description

Offer DescriptionJagiellonian University in Kraków promotes cooperation and cares for a good atmosphere based on mutual trust. It implements the strategy resulting from The Human Resources Strategy for Researchers, creating stable conditions for employment as well as the development of academic career, which resulted in the award of the HR Excellence in Research by the European CommissionJob offer no. 1227.1101.55.2025RECTOR of the Jagiellonian University
announces
a selection procedure for the position of
an ASSISTANT PROFESSORProject Title: Inducing molecular proximity to modulate cellular polyamine metabolism First Team FENG, Grant agreement no. FENG.02.02-IP.05-0228/23, competition no. 1/2023, PSP: S/FS0/0402, PRIORITY 2 OF THE PROGRAMME EUROPEAN FUNDS FOR SMART ECONOMY 2021-2027 (FENG)Field of science: Sciences and life sciences
Discipline: Biological Sciences or Chemical sciences
Scope: Structural biology, biochemistry, medicinal chemistry, molecular biology, biophysics, synthetic chemistry or relatedNumber of posts: 1
Type of employment: Fixed-term employment contract
Working time: Full- time
Planned duration of employment: 12 months, possibility of extension until the end of the project
Expected date of employment commencement: second quarter 2024
Remuneration: according to the Rules for Remunerating Jagiellonian University Employees
~160 000 gross PLN/yearProject description:
The research project focuses on developing innovative strategies for modulating polyamine metabolism by inducing molecular proximity between proteins that are key to this process. The project aims to develop new molecules that induce proximity in the polyamine metabolism pathway by combining methodologies such as crystallographic fragment screening, imaging of protein complexes, and studies of cellular polyamine metabolism. The goal is to create a bifunctional molecule that stabilizes the complex of ornithine decarboxylase (ODC) and antizyme (Az), which are crucial for polyamine metabolism. Additionally, the project aims to develop the first-in-class modulator of the hypusination process, a unique modification of the eIF5A factor essential for protein translation. Structure-based studies of protein-molecule complexes and their chemical optimization are key to the project’s success. The experiments will be supported by data analysis from various research techniques, including cryo-electron microscopy. The studies will be validated at the enzymatic and cellular levels to assess the efficacy of the developed molecules. The project will contribute to the development of novel strategies for modulating polyamine metabolism and the creation of new research tools with therapeutic potential.Scope of duties:According to the Work Regulations of the Jagiellonian University Annex 1 to the Work Regulations of the Jagiellonian University – Model scopes of responsibilities and duties of academic teachers.The hired person will be responsible for independently coordinating tasks, making rational and logical decisions to solve problems, and introducing new techniques and tools. The best-selected candidate will be required to learn and optimize new methods in the fields of structural biology, biochemistry, biophysics, and medicinal chemistry. The work will include optimizing selected activity assays, conducting experiments based on activity tests, designing new bifunctional molecules, preparing samples for structural studies, and preparing reports.Where to apply E-mailjob.mcb@uj.edu.plRequirementsResearch Field Biological sciences Education Level PhD or equivalentResearch Field Chemistry Education Level PhD or equivalentSkills/QualificationsThe selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to § 165 of the Statute of the Jagiellonian University:

• holding at least a doctoral degree;
• having relevant scientific achievements;
• taking active part in scientific life.

Specific RequirementsAdditional requirements and expectations:Ideal candidates:

• have relevant scientific background in cell biology, molecular biology, biochemistry and/or related fields,
• have at least one original scientific publication, in which they are the lead author,
• take an active part in scientific life manifested in particular in presentations at conferences and symposia
• meet the FNP requirements for persons employed in research projects as a Young Doctor (up to 7 years after obtaining a doctoral degree ( )

In addition, the candidate is expected to have prior knowledge and experience in at least one of the following of the listed methods:

• Experience in research in the fields of structural biology (X-ray crystallography or cryo-EM), biochemistry, biophysics, protein-protein interaction studies, drug design, screening techniques, peptide design, DNA/RNA aptamer design, molecular biology, biophysics, and related topics.

The ideal candidate will possess:

• Knowledge of recombinant and native protein purification techniques.
• Knowledge of molecular biology methods such as cloning, expression construct design, Western blot, RT-PCR.
• Knowledge of prokaryotic and eukaryotic protein expression systems.
• Experience in studying protein activity using various enzymatic assays.
• Experience in macromolecule structure analysis.
• Experience in the discovery and/or design of bifunctional compounds, such as those from the class of molecular glues.
• Experience in synchrotron measurements or cryo-EM.
• Experience with methods such as SPR, HPLC, MST.
• Proficiency in English at a communicative level, enabling daily work in an international scientific environment, presenting results, and preparing scientific articles.
• Familiarity with basic MS Office programs and optionally with the Linux operating system environment and software such as CCP4, Phenix, Relion, CryoSpark, PyMol, GraphPad/Origin.

Languages ENGLISH Level ExcellentAdditional InformationBenefitsWe offer:

• stable employment based on an employment contract at the renowned university,
• cooperation with the interdisciplinary academic community represented by well-known scientists,
• scientific support as well as the possibility of qualifications improvement and professional development,
• access to research infrastructure,
• benefits in the form of i.a. Multisport card, sports activities, medical packages, group insurance,
• additional social benefits.

Selection processRequired application documents:

• resume,
• personal questionnaire filled in by the candidate,
• copy of the Doctoral diploma and, if applicable, of the candidate’s Habilitation diploma,
• information on the candidate’s scientific, teaching and organizational achievements,
• declaration of the candidate, confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,
• statement under Article 113 of the Law on higher education and science,
• statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialization in force at the Jagiellonian University,

Declaration forms (no. 5-7) and personal questionnaire template (no. 2) can be obtained at:Additional application documents:1. list of publications (along with the respective publishing houses and the number of pages), if any,
2. recommendation concerning the candidate’s predisposition to work as an academic teacher and research work, including the results of student surveys and evaluations, if the candidate was subject to such evaluation.The course of selection procedure:The first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate. The Candidate has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment.
The selection procedure is conducted in accordance with The Policy of Open, Transparent and Merit-Based Recruitment Process at the Jagiellonian University.Additional commentsForm of submission:
by e-mail to the address: , title: 55.2025 assistant professor First Team FENGDeadline for submission of applications: 06.04.2025
Expected date of the selection procedure settlement: 15.05.2025
Method of communicating of the results of the selection procedure: by e-mailIn the selection procedure, the Jagiellonian University follows the principles of the European Charter for Researchers and a Code of Conduct for the Recruitment of Researchers.Jagiellonian University does not provide housing.Work Location(s)Number of offers available 1 Company/Institute Malopolska Centre of Biotechnology JU Country Poland GeofieldContact State/ProvinceMalopolska CityCracow WebsiteStreetGronostajowa 7a Postal Code30-387STATUS: EXPIREDShare this page

Expected salary

Location

Kraków, małopolskie

Job date

Fri, 07 Mar 2025 23:57:27 GMT

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