Associate Clinical PBPK Modeler, Clinical Pharmacology and Quantitative Pharmacology (CPQP)

Job title:

Associate Clinical PBPK Modeler, Clinical Pharmacology and Quantitative Pharmacology (CPQP)

Company:

AstraZeneca

Job description

Job DescriptionThe ideal candidate will have strong background in pharmacokinetics and translational modeling. You will participate in implementing innovative and quantitative approaches to advance clinical drug development. The position will involve conducting mechanistic PBPK using clinical data to support the clinical development of drug candidates across therapy areas. In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP) as per your experience, interests, and expertise dictate.Typical AccountabilitiesUtilize physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questionsCollaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic modelsValidate the mechanistic models to the level of being able to be used in Regulatory submissions and to influence the design of clinical trialsCommunicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictionsKeep up to date with emerging literature, modeling science, and regulatory expectationsEducation, Qualifications, Skills and ExperienceKnowledge of pharmacokinetics and Model-Informed Drug Development (MIDD)Demonstrated broad translational development expertise and experience exemplified by 0-4 Years of drug development experience, with emphasis on PBPK modellingGood knowledge in pharmacology, drug targets and core disease areasDemonstrated ability to identify, develop and execute PBPK activities at a project levelGood oral and written communication skillsGood knowledge of global regulatory, compliance, processes, standards and issues specific to PBPKPhD degree with relevant experience requiredRelevant regulatory experience (written)Training and experience with PBPK and other relevant software (e.g., SimCYP, GastroPlus, PK-Sim, Phoenix WinNonlin)Fluency in spoken and written English languageDate Posted 05-abr-2024Closing DateAstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Expected salary

Location

Barcelona

Job date

Sun, 07 Apr 2024 01:43:56 GMT

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