Associate Principal Scientist, Translational PKPD Modeling & DMPK (Oncology)

Job title:

Associate Principal Scientist, Translational PKPD Modeling & DMPK (Oncology)

Company:

AstraZeneca

Job description

Position: Associate Principal Scientist, Translational PKPD Modeling & DMPK (Oncology)Location: Cambridge, UKCompetitive Salary & Excellent Company BenefitsDo you have expertise in Oncology, and a passion for PKPD modeling and DMPK science, applied to Cancer biology? Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!We currently have an exciting Associate Director opportunity for someone who has a passion for PKPD modeling and DMPK science, applied to Cancer biology, ideally with experience of working with biologics drug projects to join our team.About AstraZeneca:
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.Oncology DMPK departmentThe Oncology DMPK department provides drug metabolism & pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio.Be part of fulfilling our ambition to be world leaders in Oncology. There are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio, we are confident we can change the practice of medicine and redefine cancer treatment.We’re brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever-evolving environment.What You’ll Do
As Associate Director, Translational PKPD Modeling & DMPK you will have the opportunity to apply your expertise in PKPD modeling and simulation to advance our understanding of cancer biology and accelerate drug discovery.Your day-to-day role is to provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.Key Responsibilities:

• Represent Oncology DMPK, providing scientific leadership in cross-functional and external collaborations.
• Develop and utilize PKPD models to explore the effects of target and pathway modulation, defining candidate drug target profiles.
• Predict human dose and regimen, contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.
• Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.
• Lead and participate in strategic scientific initiatives, continuous improvement projects, and external collaborations with academic or pre-competitive groups.
• Mentor students and postdoctoral fellows, contributing to the next generation of scientific talent.
• Present findings through publications, patents, and lectures, enhancing the visibility of AstraZeneca’s translational research.

What You Bring:

• Ph.D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences, or applied mathematics.
• Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting.
• Essential to have experience / expertise in Translational Modelling & Simulation of biologics, including T-cell engagers and desirable to also have experience with small molecules too.
• Experience in a project-facing role within pharmaceutical R&D.
• Strong understanding of DMPK and pharmacology in drug discovery, with a track record of delivering results in a fast-paced environment.
• Proficiency with tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
• Excellent interpersonal, communication, and leadership skills, with a passion for collaborative problem-solving.

Why AstraZeneca?
At AstraZeneca, we seize opportunities to innovate and redefine what’s possible in biopharmaceuticals. Our mission to deliver transformative medicines is underpinned by a culture of collaboration, inclusivity, and ambition. Join us in a role where your work directly contributes to breakthroughs in oncology, empowering patients and changing lives.Interested? Apply Now!Closing date for Applications: COB 5th September 2025Date Posted 19-Aug-2025Closing Date 05-Sept-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Expected salary

Location

Cambridge

Job date

Thu, 21 Aug 2025 02:25:14 GMT

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