Engineer or researcher position to explore genomic architecture of disease resistance in Crassostrea gigas (M/F)

Job title:

Engineer or researcher position to explore genomic architecture of disease resistance in Crassostrea gigas (M/F)

Company:

Ifremer

Job description

Description du poste et MissionsDeadline for applications: March 3rd 2025Presentation of the host structureThe ASIM unit (Amélioration et Santé des Invertébrés Marins – Improvement and Health of Marine Invertebrates), located at the La Tremblade station, focuses on developing skills and acquiring knowledge in the field of the health of species of interest in marine aquaculture, with a particular emphasis on bivalve molluscs, interactions with associated pathogenic organisms, and the genetic basis of responses implemented by protagonists evolving in an open and changing environment.Our team conducts research into recurrent mass mortalities affecting the Crassostrea gigas oysters. Particular attention has been paid to resistance to infection by OsHV-1 and Vibrio aestuarianus, the two major pathogens affecting the French oyster farming industry. As part of the Newtechaqua project, experimental infections were carried out on a batch of 100 oyster families produced by our team at the marine mollusc platform at La Tremblade. Several QTLs associated with OsHV-1 resistance and coinfection have been identified.As part of an innovative European project named Shellfishboost, the objectives are to carry out complementary analyses for vibriosis and to participate in the development of a new genotyping chip to refine the position of current QTLs, and detect new ones.The position will be located within the ASIM unit’s research team at the Ifremer station in La Tremblade, under the authority of the unit manager. He/she will work in close collaboration with laboratory researchers and the Sysaaf (Syndicat des sélectionneurs avicoles et aquacoles français), and he/she will have access to the Ifremer Datarmor server.Main missionsFrom dead and survivors of experimental infection, the candidate will select new samples for genotyping, and will also participate for the detection and quantification of the virus and the bacteria in dead oysters. He/She will be in charge to analyze the new genotyping data (medium density array), along with those already done lately, and perform pedigree analysis, GBLUP, PBLUP and GWAS. In addition, a high density SNP array is under developing in the Shellfishboost project. So, parents will be genotyped using the new array, and applicant will perform imputation for all samples genotyped with the medium density array, in order to refine the QTL detected for single and dual experimental infections. Results will be presented to the partners of the Shellfishboost project, as well as in international conference, publication and report.Profil recherchéPhD in quantitative genetics or high experience with:

• Estimation of genetic paremeters (h², rg…) from pedigree and genomic data,
• Exploring genomic architecture through GWAS and selection accuracy,
• Pedigree analysis, and imputation tools,
• Good knowledge working in linux environment,
• Basic molecular biology (DNA extraction, qPCR),

Informations utiles

• Localisation Nantes – 44, France – zone de déplacement : internationale
• Contrat CDD – 9 mois
• Salaire Non défini
• Niveau de qualification Ingénieur/Cadre/Bac +5
• Expérience – 1 an, 1 à 7 ans
• Modalités de travail Temps complet
• Fonction Ingénierie – Chimie/Pharmacie/Bio.
• Secteur Secteur Energie/Environnement, Service public autres
• Télétravail Pas de télétravail

• Site: La Tremblade, France
• Position: temporary 9 mois
• Salary: to be defined
• Education: Engineer, PhD

Qui sommes nous ?Ifremer 1625 Route de Sainte Anne – 29280 Plouzané • 29280 Plouzané • FranceThe InstituteA pioneer in ocean science, IFREMER’s cutting-edge research is grounded in sustainable development and open science. Our vision is to advance science, expertise and innovation to :
– Protect and restore the ocean
– Sustainably use marine resources to benefit society
– Create and share ocean data, information & knowledge.With more than 1,500 personnel spread along the French coastline in more than 20 sites, the Institute explores the 3 great oceans : the Indian, Atlantic and Pacific oceans. A leader in ocean science, IFREMER is managing the French Oceanographic Fleet and its dedicated scientists create ground-breaking technology to push the boundaries of ocean exploration and knowledge, from the abyss to the atmosphere-ocean interface.Well-established in the international scientific community, our scientists, engineers and technicians are committed to advance knowledge about our planet’s last unexplored frontiers. They provide the science we need for informed decision-making and public policy and they transfer this knowledge and technology to businesses to fulfill public and private needs. Core to our mission is also to strengthen public awareness about the importance of understanding the ocean and its resources, and empowering future generations of leaders through education and outreach national campaigns.

Expected salary

Location

Nantes, Loire-Atlantique

Job date

Thu, 06 Feb 2025 23:51:27 GMT

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