Laboratory Research Scientist

Job title:

Laboratory Research Scientist

Company:

Francis Crick Institute

Job description

Salary for this Role:£31,675 – £35,900, with benefits, subject to skills and experience.Job Title: Laboratory Research ScientistReports to: Adrian Hayday [C]Closing Date: 18/Mar/2025 23.59 GMTJob Description:Laboratory Research Scientist in the ImmunoSurveillance LabReports to: Adrian HaydayContact term: This is a full-time, fixed term position for up to 12 months on Crick terms and conditions of employment.SummaryA position is immediately available for a fixed-term Laboratory Research Scientist (LRS) in the ImmunoSurveillance laboratory, headed by Professor Adrian Hayday. The lab is located at The Francis Crick Institute in London and focuses on investigating tissue-associated T cells and their contributions to protection against epithelial perturbations that characterise inflammatory diseases and cancers.The post holder will work under the supervision of Professor Hayday and Dr Vivien Kohlhaas, providing experimental support in a state-of-the-art model system study seeking to dissect how the dysregulation of local intestinal T cells may combine with altered diet to provoke gut inflammation. The hypothesis that this may be an important axis in inflammatory bowel disease, and potentially in colorectal cancer, is fuelled by epidemiologic data and our own genetic and imunological studies of human patients. The ideal candidate is likely to be a pro-active, focused and productive individual, motivated by the development and study of a model system to better understand complex human disease. They will also be motivated by the collegial and collaborative work environment, that uses a team ethic to nurture and promote individual excellence. Excellent time management, communication, attention to detail and organisation skills are essential.The Research GroupProfessor Hayday’s laboratory discovered specific proteins expressed by epithelial cells that regulate the composition and activity of gamma delta T cells that naturally populate body surfaces in model animals and in humans. His team is responsible for the ‘Lymphoid Stress Surveillance’ hypothesis (PMID) that has more recently led to the concept of “normality sensing” (PMID). These concepts describe how tissue-associated T cells recognise and respond rapidly to perturbations of epithelial cells that may occur in response to infection or physical and/or chemical stress. Although under-explored, this biology appears fundamental, being conserved as far back as jawless (agnathan) vertebrates. Moreover, the group has provided substantial scientific evidence that this biology can in humans make significant contributions to tumour surveillance and to protection against severe forms of inflammatory bowel disease.Wu et al, 2022 PMID: 35637401Hayday et al., 2024 PMID: 39361750Dart et al., 2023 PMID: 37708268Details of research projects currently being undertaken can be seen at:Key responsibilitiesThese include but are not limited to:Contribute to specific research projects under the Group Leader’s supervisionContribute to tissue-culture experiments in which the responses of T cells to different stimuli are studied. Generation of stable stimulator cell linesAnalysis of cell activation in an in vitro culture system using flow cytometryContribute to omics experimentsContribute to data analysisSupporting some aspects of in vivo experiments, including tissue collection, processing and analysis.Keep accurate records of all work carried out.Attend and contribute to group meetings, journal club and interest group meetings.Key experience and competenciesThe post holder should embody and demonstrate our core Crick values: bold, open and collegial, in addition to the following:EssentialBSc or MSc in Immunology, Metabolism, Biology, Biochemistry, Biomedical Sciences, or Molecular BiologyProficiency in key aspects of cell culture and sterile techniqueFluent with PCR and other basic molecular techniquesExperience in flow cytometryFirm understanding of experimental design principlesStrong quantiatational skillsGrowing capacity and desire to work independently, and also be capable of interacting within a groupStrong organisational and record-keeping skillsAbility to describe and present dataDesirableA PhDExperience doing experimental research in a field involving immunology, metabolism, and/or molecular biologyExperience with epithelial cell biologyExperience with lentivirus/retrovirus production and application to mammalian cellsExperience with animal handling and tissue processingHolder of UK Animal scientific procedures personal licenceThe post involves undertaking specific research projects, under the guidance of the Group Leader and his post-doctoral associate, Dr Kohlhaas. Applicants should have demonstrated a growing capacity to carry out independent basic research projects once the goals and approaches are clearly outlined.About UsAt the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.If you are interested in applying for this role, please apply via our .All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.If you require a visa to work in the UK we will help support your application should you be successfulFind out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

£31675 – 35900 per year

Location

London

Job date

Thu, 13 Mar 2025 02:31:05 GMT

To help us track our recruitment effort, please indicate in your email/cover letter where (vacanciesin.eu) you saw this job posting.