Marie-Curie Doctoral Network PhD

Job title:

Marie-Curie Doctoral Network PhD

Company:

Dublin City University

Job description

Job Information Organisation/CompanyDublin City University DepartmentHuman Resources Research FieldOther Researcher ProfileFirst Stage Researcher (R1) PositionsPhD Positions CountryIreland Application Deadline14 Apr 2025 – 23:59 (Europe/Dublin) Type of ContractTemporary Job StatusFull-time Is the job funded through the EU Research Framework Programme?Other EU programme Reference Number002908 Is the Job related to staff position within a Research Infrastructure?NoOffer DescriptionResearch Centre – School of Chemical SciencesPosition title – Marie-Curie Doctoral Network PhD Position (x2)Post Duration – 3 year fixed term contractDublin City UniversityDublin City University (DCU) is a leading innovative European University, proud to be one of the world’s leading Young Universities. DCU is known as Ireland’s University of Impact, with a mission to ‘transform lives and societies’ and focuses on addressing global challenges in collaboration with key national and international partners and stakeholders.DCU has over 20,000 students in five faculties spread across three academic campuses in the Glasnevin-Drumcondra area of North Dublin. Thanks to its innovative approach to teaching and learning, the University offers a ‘transformative student experience’ that helps to develop highly sought-after graduates. DCU is currently No. 1 in Ireland for Graduate Employment Rate, and for graduate income (CSO).DCU is a research-intensive University and is home to a number of SFI-funded Research Centres. The University participates in a range of European and international research partnerships. DCU is also the leading Irish university in the area of technology transfer as reflected by licensing of intellectual property.As a ‘People First’ institution, DCU is committed to Equality, Diversity and Inclusion – a University that helps staff and students to thrive. The University is a leader in terms of its work to increase access to education, and is placed in the world’s Top 10 for reducing inequalities in the Times Higher Education Impact Rankings.Overview of the departmentThe School of Chemical Sciences is one of Ireland’s most progressive and highest achieving Schools with outstanding facilities, housed within a modern city campus. We strive for teaching and research excellence by helping students to develop critical thinking and problem solving. We prepare our students to meet the challenges of modern industry and cutting-edge research environments.The School is one of the most successful in Ireland at attracting large-scale research funding. Our researchers are recognised as leaders at both national and international levels.Our courses cover the fundamental principles and practice of chemical, pharmaceutical, analytical and environmental sciences, built to create an outstanding and stimulating educational experience. Our students experience lab-based environments while enjoying the engagement with research active staff members.Our graduates are nationally and internationally regarded by prospective employers and research bodies. We offer a supportive and innovative learning environment for students, researchers, staff and collaborators.Role ProfileThis is an opportunity to join a Marie Slodowska Curie Doctoral Network (MeCHaNiSM) as PhD researcher. This is a largescale Horizon Europe-funded program that will employ 15 Doctoral Candidates (DC) across seven European countries to complete their PhD training in nucleic acid-based chemistry and biotechnology fields.The overarching aim of the MeCHANiSM research programme is the Mechanical Characterisation of Nucleic Acids using Single Molecule methods. MeCHaNiSM researchers will be trained within an innovative, multi-disciplinary and entrepreneurial environment so that they can meet the challenges facing future scientific leaders in European industry. More specifically, this project will provide world-class training to 15 PhD students in the areas of single molecule analysis, synthetic click chemistry, nucleic acid chemistry, DNA crystallography, molecular biology and materials chemistry.Each DC will be registered on the structured PhD program at Dublin City University within the School of Chemical Sciences under the supervision of Professor Andrew Kellett.Description of research field:Nucleic acids (NAs) are central to the storage, transmission, and regulation of genetic information. DNA carries the genetic information for all cellular life, while RNA plays many diverse roles. These include not only the traditional roles of messenger-, transfer- and ribosomal-RNA, but also many regulatory functions such as gene silencing in RNA interference, precision nuclease targeting in CRISPR/Cas, and in providing the blueprint for mounting mRNA vaccine immune responses to combat SARS-CoV-2. Significantly, the genetic material of many viruses, including influenza, HIV and SARS-CoV-2, consist of RNA folded into complex 3D structures. Single-molecule techniques have revolutionized the understanding of complex NA structures and their interactions with therapeutic oligonucleotides, small molecules, and proteins. However, for Europe to adapt to new therapeutic challenges1 and to increase its competitiveness, new expertise is urgently required in single-molecule analysis of NAs, a research field that intersects physical chemistry, biophysics, chemical synthesis, and molecular simulation. MeChaNiSM will train the next generation of European scientific leaders in the development of single-molecule biophysics techniques to investigate critical, cross-disciplinary questions regarding the structure, dynamics, function, and interactions of NAs.A more detailed overview of the MeCHaNiSM can be found .Project description:Position 1:Development of hybrid gene editing systems using nucleic acid click chemistry (DC8)The main areas of expertise/skills required by the candidate: Inorganic chemistry, synthetic organic chemistry, heterocyclic chemistry, nucleic acid chemistry, molecular biology / chemical biology.Training will involve synthesis of gene-targeting triplex-forming oligonucleotides, click chemistry, inorganic synthesis, nucleic acid biophysics, single-molecule analysis, DNA damage and repair, and nucleic acid chemistry.This project will be conducted in collaboration with Chalmers University of Technology (Sweden) and the National Institute for Bioprocessing Research and Training (Ireland).Position 2:Development of click chemistry-derived targeted Holliday junction probes (DC14)Main areas of expertise/skills required by the candidate: Inorganic chemistry, synthetic organic chemistry, heterocyclic chemistry, nucleic acid chemistry, molecular biology / chemical biology.Training will involve synthesis of gene-targeting triplex-forming oligonucleotides, click chemistry, inorganic synthesis, nucleic acid biophysics, single-molecule analysis, DNA damage and repair, and nucleic acid chemistry.This project will be conducted in collaboration with Universitat de Barcelona (Spain) and University of Amsterdam (Netherlands).Qualifications and ExperienceMinimum Criteria

• Applicants are required to have an B.Sc. honours degree (or equivalent) in organic, inorganic, medicinal or pharmaceutical chemistry. An M.Sc. (or equivalent) is preferred
• An excellent track record in laboratory skills directly related to the specific project you are applying for is essential

Desirable Criteria

• Applicants with experience in biochemistry and chemical biology is desirable.
• Applicants who hold an M.Sc. (or equivalent) is preferred
• Excellent communication skills in English, both written and spoken, are a necessity.

EligibilityApplicants from all countries are eligible. However, as the network aims to foster international collaborations, applicants who are Irish nationals are only eligible for this post if they have lived or carried out their main activity in another country for more than 24 months of the past 36 months.ConditionsAs a Marie Curie Doctoral Candidate-recruit, you shall at the time of recruitment be in the first four years (full-time equivalent research experience) of your research career and have not yet been awarded a doctoral degree. At the time of recruitment, you shall not have resided or carried out your main activity (work, studies etc.) in the country of the host institution (Ireland) for more than 12 months in the 3 years immediately prior to the reference date. Compulsory national service and/or short stays such as holidays are not taken into account.Essential TrainingThe postholder will be required to undertake the following essential compliance training: Orientation, Health & Safety, Data Protection (GDPR) and all Cyber Security Awareness Training. Other training may need to be undertaken when required.Salary Scale:€43,653 – €48,997Appointment will be commensurate with qualifications and experience and in line with current Government pay policyRemote Working PolicyFrom the 1st of November 2024, DCU will operate its newly agreed . Employees may be approved for up to 2 days of remote working per week (or an appropriate pro rata amount for those part time). Any remote working arrangement will be reflective of the predominant on-campus working environment and the core University value of ‘Student Focused’. Employees will be based on campus for the majority of their working week to ensure a sustained on campus engagement and experience. The terms of the remote working policy will apply.For more information on DCU and our benefits, please visitInformal Enquiries in relation to this role should be directed to:Professor Andrew Kellett, School of Chemical Sciences, Dublin City University.Phone + 353 (0)1 7005461 Email:Please do not send applications to this email address, instead apply as described below.Application Procedure:Please submit your application through the online system at , in order to be considered for the role to which you are applying for, you must upload:1) Curriculum Vitae2) Cover Letter explaining why you are interested in pursuing a PhD in this area.3) Completed application form (blank forms can be downloaded from the bottom of the Vacancy).Please note, if all items are not uploaded, the application will be deemed incomplete, and will not be processed.Dublin City University is an equal opportunities employer.In line with the Employment Equality Acts 1998 – 2015, the University is committed to equality of treatment for all those who engage with its recruitment, selection and appointment processes.The University’s Athena SWAN Silver Award signifies the University’s commitment to promoting gender equality and addressing any gender pay gaps. Information on a range of university policies aimed at creating a supportive and flexible work environment are available in theWhere to apply WebsiteRequirementsResearch Field Other Education Level Bachelor Degree or equivalentInternal Application form(s) neededAcademic and Research Application Form Updated Jan 24 (2)_0.pdfEnglish(217.03 KB – PDF)Additional InformationWork Location(s)Number of offers available 2 Company/Institute Dublin City University Country Ireland GeofieldContact CityDublin WebsiteStreetGlasnevin Postal CodeDublin 9STATUS: EXPIREDShare this page

Expected salary

€43653 – 48997 per year

Location

Dublin

Job date

Wed, 02 Apr 2025 05:36:40 GMT

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