Mechanical forces in intestinal epithelial renewal and integrity

CNRS | Centre de Biologie Integrative

19 May 2023
Job Information

CNRS Centre de Biologie Integrative
Research Field
Biological sciences
Researcher Profile
First Stage Researcher (R1)
Application Deadline
10 Jun 2023 – 23:00 (UTC)
Type of Contract
To be defined
Job Status
Hours Per Week
To be defined
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

Offer Description

Our young and growing team “Gut Development and Homeostasis ”, led by Denis Krndija, is looking for a highly motivated and enthusiastic student.

The gut epithelium is one of the fastest-renewing tissues in the body (3-5 days), and is unique for withstanding continuous mechanical, chemical and biological insults whilst maintaining renewal and barrier function throughout adult life. We have recently showed that intestinal epithelial cells exert active migratory forces and that active migration is critical for steady-state tissue turnover in the adult mammalian gut (Krndija et al., Science 2019).
Our goal now is to define how the epithelial tissue renewal and barrier integrity are maintained in adult gut homeostasis in the presence of tissue-intrinsic and extrinsic mechanical forces. The PhD student will work at the interface of cell biology, physiology and physics, and use state-of-the-art approaches, including live tissue imaging with laser nanosurgery, genetic and force perturbations in novel mouse models, organ-on-chip and proteomics. The work will be performed at the CBI and in association with our collaborators at the IRSD (gut pathophysiology) and LAAS (experimental biophysics) in Toulouse.

The candidate should hold a Master’s degree in cell biology and/or developmental biology, and have a strong interest in epithelial tissue homeostasis and tissue mechanics. Experience in imaging, image analysis, mouse models and/or tissue culture will be an advantage. Training will be provided on-site for approaches specific to our group. The student should be able to work as a part of a team, be self-driven and organised, with good written and spoken communication skills in English.
We are an equal opportunity employer, committed to creating a diverse, multicultural and inclusive environment. We encourage applications from candidates from different socioeconomic and under-represented backgrounds.

We are located at the Centre for Integrative Biology of Toulouse (CBI) in a brand-new building on the main campus of the Université Toulouse III-Paul Sabatier. The CBI offers a very dynamic and collaborative scientific environment (40 research groups) and in-house state-of-the-art core facilities and platforms.
Toulouse is a warm and vibrant city situated in the heart of southwest France, home to one of the oldest European universities, rich in culture and history, and offering excellent life quality.

Application details 
Please send your CV incl. contact details of two referees and a motivation letter to Denis Krndija.
Applicants will have to apply for a fellowship through a selective process of the doctoral programme of the Graduate School of the University of Toulouse.

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CNRS Centre de Biologie Integrative

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