PhD fellowship: Cardiac adipose tissue in the pathogenesis of atrial fibrillation

Job title:

PhD fellowship: Cardiac adipose tissue in the pathogenesis of atrial fibrillation

Company:

Københavns Universitet

Job description

A position is available in the Cardiac Physiology Laboratory at the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. The position is available from 10 November 2025, or as soon as possible hereafter. Very motivated and committed candidates with experience in cardiovascular research and biomedicine are invited to apply. The employment as a PhD fellow is full time and for 3 years. The position is fully funded and is conditioned upon the applicant’s successful enrollment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.The projectAtrial fibrillation (AF) is the most common cardiac arrythmia affecting more than 33.5 million people worldwide and is associated with increased morbidity and mortality occurring as a result of stroke and heart failure. An increase in body mass index is associated with a greater risk of AF and is linked to an increase in epicardial adipose tissue (EAT) which has the potential to release signaling and inflammatory molecules affecting cardiomyocytes and fibroblasts in the myocardium. However, the role of how obesity and EAT contribute to structural and electrical remodeling the atria is unknown. This project will provide novel and important insights into role of EAT and obesity in AF pathogenesis, potentially leading to development of novel treatment strategies for AF patients.SupervisionPrinciple supervisor is Professor Thomas Jespersen.Primary co-supervisor is Associate Professor Alicia D’SouzaCo-supervisor is Assistant Professor Arnela SaljicStart10 November 2025 or soon thereafterThe groupWe are an interdisciplinary and dynamic team of ambitious scientists, where both excellence in science and team-spirit are the primary objectives. The team includes PhD students, postdocs, scholar students as well as bachelor and master students. We have a large collaborative international and national network, which nurtures the group’s talent and the impact of our research.Our researchOur primary research focus is on cardiac electrophysiology and arrhythmias. We aim at elucidating cardiac electrophysiology and structural remodeling in health and disease with a specific focus on ion channels and their associated proteins and functions using molecular, biochemical, pharmacological and electrophysiological investigations. We also aim to reveal and understand how disease states affect the electrophysiological function of the heart and its ion channels. Our goal is to incorporate in vitro findings into a whole organ context through the use of ex vivo and in vivo animal models.Job descriptionYour key tasks as a PhD student are to:

• Plan, execute and evaluate independent research under supervision
• Complete PhD courses or equivalent education corresponding to 30 ECTS points
• Participating in active research environments including a stay at another research team.
• Teach pregraduate students
• Obtaining experience with teaching or other types of dissemination related to your PhD project
• Disseminate your research orally and in writing, including writing scientific articles
• Write a PhD thesis on the ground of your project

Criteria for the assessment of candidatesWe are looking for an exceptional candidate who

• has experience in cardiac adipose tissue biology
• has experience in fibroblast and cardiomyocyte biology
• has experience in molecular biology and is familiar with techniques used within molecular biology
• experience in electrophysiological in vitro techniques is an advantage
• experience in cell culturing and cell isolation is an advantage
• experience in omics is an advantage
• is driven by curiosity and desire to know more about the biomedical aspects and molecular changes that is believed to drive the pathophysiology in atrial fibrillation
• can show a great ability to collaborate, and contribute to a dynamic, strong, and inclusive working environment
• is willing to undertake international research visits (secondments)

We offer extensive training in the following techniques:

• a wide range of molecular biology, including immunoblotting, ELISA, cloning, RNA/DNA/protein extraction, qPCR, PCR, histology and immunostaining
• cell isolation and culturing techniques in primary human and animal fibroblasts and cardiomyocytes, as well as in cell lines
• cellular functional studies
• investigations in animal and human samples (blood and tissue)

QuestionsFor specific questions relating to the PhD project, please contact Arnela Saljic or at +45 42360411. General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s websiteApplication and Assessment ProcedureYour online application including all attachments must be in English and submitted electronically by clicking APPLY NOW below.Please include:

• Motivated letter of application (max. one page)
• Curriculum vitae focused on the assessment criterias outlines above. Include information about your education, laboratory experience, language skills and other skills relevant for the position. Please include a photo.
• Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database:

. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science. * Publication list (if possible)

• Contact information on two-three references

Application deadlineApplication deadline is 3 August 2025. We will not consider material received after the deadline, and will not to consider applications that do not live up to the abovementioned requirements.After the expiry of the deadline for applications, the recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at UniversitiesInterviews are expected to be held in week 36 – 37.The University of Copenhagen wishes to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Expected salary

Location

København

Job date

Tue, 01 Jul 2025 22:21:16 GMT

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