PhD student-scholarship holder at the Poznan Doctoral School of Institutes PAS, Department of Molecular Pathology IHG PAS

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PhD student-scholarship holder at the Poznan Doctoral School of Institutes PAS, Department of Molecular Pathology IHG PAS

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Job description

Offer DescriptionThe proposed study will be carried out within the PI – Tomasz Kolanowski, PhDProject title: “Development of a new generation of CAR adoptive therapy based on ATMP products” DWD/9/0366/2025Concise description of research:RESEARCH PROJECT OBJECTIVES / RESEARCH HYPOTHESESThe aim of the implementation doctorate is the development of advanced therapy medicinal product (ATMP) based on T lymphocytes containing the next generation chimeric CAR receptor (ngCAR). CAR-T therapies are currently used with high effectiveness in patients with hematologic malignancies, however, some of them experience problems with treatment effectiveness related to safety and disease relapses due to, among others, exhaustion of T lymphocytes. It is proposed to develop a product based on ngCAR, imitating the natural response of T lymphocytes in the presence of a specific antigen, to avoid excessive activation of cells and reducing the likelihood of occurrence of cytokine release syndrome and premature exhaustion of T cells. Additionally, the project assumes technological development that will allow for increasing production capabilities and optimizing the manufacturing process of the developed medicinal product.Keywords: ngCAR therapy, hematological malignancies, ATMPPredicted tasks in the project:– active participation in the realization of project goals and analysis of obtained results,– presenting results at seminars and conferences, participation in writing scientific papersOpportunities:
– work in an international research team, highly experienced in many molecular and cellular methodologies, and enthusiastic about conducting scientific research,– participation in research training, international conferences and workshops.Where to apply E-mailphdstudies@igcz.poznan.plRequirementsResearch Field Medical sciences » Health sciences Education Level Master Degree or equivalentSkills/Qualifications

• Master’s degree in molecular biology, chemistry, biotechnology, genetics, medicine or related field,
• Knowledge of molecular biology and genetic engineering as well as biology of stem cells and cancer,
• Knowledge of molecular biology techniques: PCR, RT-qPCR, Western Blot, ELISA
• Knowledge of genetic engineering techniques: designing of inserts for expression vectors and reporter assays,
• Knowledge of the basics of working with cell lines: cell lines cultures, cell lines transfection,
• Experience in work with DNA and RNA: extraction of nucleic acids,
• Experience in work in cGMP standards (B class laboratory)
• Very good written and oral communication skills in English,
• Motivation and enthusiasm about working in the field of science,
• Good collaborative and team work skills.

Specific Requirements

• CV, including research achievements.
• Cover letter.
• A copy of the diploma confirming completion of a Master’s Studies Programme, or a certificate of their completion (in the case of diplomas issued by foreign institutions , the diploma referred to in article 326 para.2 point 2 or article 327 para. 2 of the Act of 20 July 2018 – Law on Higher Education and Science (Journal of Laws of 2018, item 1668 as amended), giving the right to apply for a doctoral degree in the country in which the University of Higher Education issuing the diploma operates. If the candidate does not have the above-mentioned documents, s/he is obliged to provide them before being admitted to Poznań Doctoral School IPAS. More information about foreign diplomas is available at:

. * Contact details of at least one current supervisor or other researcher who has previously agreed to issue an opinion about the candidate. The opinion should not be included in the application.

• Consent for the processing of candidate’s personal data for the purposes of the recruitment process:
• Application for admission to the Poznań Doctoral School IPAS, together with a consent to the processing of personal data for the purposes of the recruitment procedure plus a statement on his/her familiarity with recruitment regulations for the Poznań Doctoral School (Application is available on:

) * Certificates or other documents indicating level of English language proficiency, if the candidate possesses any.Languages ENGLISH Level GoodAdditional InformationBenefitsA Phd student will receive a fellowship of about 3 935 zł till the month of mid-term assessment and about 5 997 zł – after the month when the mid-term assessment will be performed.Eligibility criteria

• Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry
• Background in molecular biology
• Candidate’s scientific achievements, based on study grades, scientific and popular science publications, scholarships; prizes and awards resulting from research carried out; student activity or other achievements
• Communication skills in English.

Selection processUp to 30 days after the deadline of documents submission. Selected candidates will be invited for interview.Additional commentsA condition of involvement in the project is participation in the Institutes of PAS (after passing the recruitment procedure). Details of the studies are available onAdditional informationAddress to which documents should be submitted: by e-mail to the Secretary for Scientific Purposes: Please, include the number of the announcement: [20/2025/IGCz/PSD] in the title of your e-mail.Applications sent after the deadline will not be considered.Once the recruitment process is finished, unsuccessful candidates will be informed about the scores they have obtained at each step of evaluation.Refusal of admission to PDS IPAS takes place by way of an administrative decision. The candidate is entitled to submit a request for reconsideration of the decision to the director of the institute concerned.Work Location(s)Number of offers available 1 Company/Institute Institute of Human Genetics of the Polish Academy of Sciences Country Poland State/Province Wielkopolska City Poznań Postal Code 60-479 Street Strzeszyńska 32 GeofieldContact CityPoznań WebsiteStreetStrzeszyńska 32 Postal Code60-479STATUS: EXPIREDShare this page

Expected salary

Location

Poznań, wielkopolskie

Job date

Thu, 07 Aug 2025 22:47:09 GMT

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