PhD student – scholarship position Recruitment no. 12/2024

Job title:

PhD student – scholarship position Recruitment no. 12/2024

Company:

Job description

Offer DescriptionWe offer a 36-month scholarship of PLN 3000 PLN per month (with possible extension to 48 months) financed from the NCN OPUS 25 Project No. 2023/49/B/ST4/01450 “Plasmonic nanoparticles decorated with fluorescently-labelled mRNA: using single-pair FRET effect for investigating enzymes active in mRNA metabolism” led by prof. Joanna Niedziółka-Jönsson. This exciting interdisciplinary project is realized in a collaboration with with Prof. Jemielity from Centre of New Technologies, University of Warsaw and prof. Maćkowski from the Nicolaus Copernicus University in Toruń.The aim envisioned in this interdisciplinary project is experimental optical detection and quantification of the activity of the enzymes responsible for mRNA degradation using a novel double-labelled nucleotide and mRNA-based fluorescent probes. The optical response of those probes can be strongly enhanced if chemically grafted to plasmonically active silver nanowires. Therefore, careful control of the surface modification of the plasmonic particles is required so that the distance between the particle and the probe is adjusted to ensure efficient enhancement of the fluorescence. The approach with plasmonic particles should give the opportunity to monitor the reaction at a single-molecules level and the activity in real time.Responsibilities:

• Investigation of enzymatic activity for double-labelled nucleotide probes featuring the FRET effect after chemical grafting to plasmonically active silver nanowires.

• Investigation of enzymatic activity for double-labelled mRNA probes featuring the FRET effect after chemical grafting to plasmonically active silver nanowires.

• Investigation of enzymatic activity for double-labelled nucleotide and mRNA FRET probes densely packed on silver nanowires.

• Investigation of enzymatic activity for individual FRET probes grafted to silver nanowires

RequirementsResearch Field Chemistry Education Level Master Degree or equivalentResearch Field Physics Education Level Master Degree or equivalentSkills/Qualifications

• completed Master’s degree in chemistry, physics, biotechnology or related field.
• Enthusiasm and engagement in the scientific work.
• Basic knowledge of physical chemistry, nanomaterials, biologically active compounds, molecular interactions, fluorescence microscopy.
• Good knowledge in English.

Specific Requirements

• Knowledge of mRNA and enzymes is a plus.

Languages ENGLISH Level GoodResearch Field ChemistryPhysics Years of Research Experience 1 – 4Additional InformationBenefits

• 36-month scholarship of PLN 3000 PLN per month (with possible extension to 48 months) financed from the NCN OPUS 25 Project No. 2023/49/B/ST4/01450
• A job in an exciting interdisciplinary project, realized in a collaboration with Prof. Jemielity from Centre of New Technologies, University of Warsaw and prof. Maćkowski from the Nicolaus Copernicus University in Toruń.
• You will learn advanced optical microscopy techniques.
• You will learn how to perform single-molecule measurements on a fluorescence microscope.
• You will perform measurements of enzyme activity using FRET.

The successful candidate will gain an experience in optical detection and quantification of the enzyme activity responsible for mRNA degradation which may influence metabolism, gene expression, signalling and etc. The investigation of the photonic control of light-matter interaction at the nanoscale can be beneficial in construction of new hybrid systems based on RNA. The successful candidate will be able to take advantage of all programs in the IPC PAS, including Young Scientists of IPC PAS competition and Mobility of Young Scientists of IPC PAS competition. The Institute provides an opportunity to participate in ERASMUS+ program.Eligibility criteriaNCN scholarships may be awarded to a person who is a PhD student at a doctoral school at a university or institute of higher education in Poland.Selection processRequired documents:

• Curriculum vitae, including a list of scientific achievements (scholarships, awards, publications, patents, conference presentations, research experience gained in Poland or abroad, research workshops and training courses, etc.)
• Recommendation letter(s). At least one opinion of the candidate from a specialist in a relevant field of science.
• Motivation letter.
• Confirmation of having the status of PhD student enlisted in doctoral school at a university or institute of higher education in Poland.

The Commission will take into account the following criteria and evaluate applications on a point scale:

• the candidate’s research achievements, including publications in prestigious academic press /journals (50% of the final score)
• research-related achievements, scholarships, awards and research experience gained in Poland or abroad, research workshops and training courses, participation in research projects (20% of the final score)
• the candidate’s competence to carry out specific tasks in the research project (30% of the final score).

and the Employment policy of the Institute of Physical Chemistry PASThe Commission will analyze CVs of the candidates. The top candidates will be invited for an online interview (29.04.2024). Good command of English is required. We reserve the right to contact and reply only to selected candidates.– The incomplete applications will be not considered.– The scholarship will be awarded to the person who obtains the highest number of points.– The results of the competition are made public.– If the top candidate does not sign the contract, due to the resignation, we reserve the right to choose the next candidate from the ranking list.The results of the recruitment are planned to be announced on 30.04.2024.Scheduled date of starting work within the Project: 01.05.2024.Additional commentsHow to Apply: Send application directly to ;IMPORTANT: email title “Recruitment 12/2024”; (emails without this number will be not considered!)By submitting the application you consent to the processing of your personal data in the recruitment process.The controller of your personal data is the Institute of Physical Chemistry of the Polish Academy of Sciences with its registered office in Warsaw, NIP: 5250008755 (the “Institute”). The Institute will process your data for the purpose of carrying out scientific and research activities, providing services and contact with the Institute, on the basis of a contract (in connection with the performance of the contract or in order to take action on your request before the contract is concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal provisions (Article 6, paragraph 1, letter c) of the GDPR) – depending on the circumstances.You have the right to: request access to your data, receive a copy of it; rectify (correct) it; delete it; limit its processing; transfer it; lodge a complaint to the supervisory body; withdraw your consent for processing at any time (withdrawal of consent does not affect the lawfulness of the processing carried out prior to its withdrawal) or to lodge an objection to data processing. More information is available on the Institute’s website.Work Location(s)Number of offers available 1 Company/Institute Institute of Physical Chemistry Polish Academy of Sciences Country Poland City Warsaw Postal Code 01-224 Street Kasprzaka 44/52 GeofieldWhere to apply E-mailrekrutacja@ichf.edu.plContact CityWarsaw WebsiteStreetWarsaw, Kasprzaka 44/52 Postal CodePL-01-224 E-Mailjniedziolka@ichf.edu.pl Phone+48 22 343 3130STATUS: EXPIRED

Expected salary

3000 per month

Location

Warszawa, mazowieckie

Job date

Tue, 09 Apr 2024 22:21:56 GMT

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