Post-Doc
Sanofi
Post-Doc Position in Sanofi / WIDGET consortiumExpert in Biology, Molecular Biology, NGS & Single CellsAbstract:As part of the WIDGeT consortium1 (23M€, 5 years), we are currently researching a Postdoctoral candidate with a strong background in molecular biology and NGS for single cell application.Overview of the research project:The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV’s transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS.Responsibilities:· Develop, design, and execute complex experiments and analyze data.· Write (Lab Book) and Present (PowerPoint) research findings.· Mentor and co-supervise engineer, technician and undergraduate students involved in the research project.· Report and collaborate with other members of the consortium.Qualifications :· Ph.D. in biology or molecular biology· Strong Experience in Single-cell RNA sequencing· Strong background in molecular biology, NGS experiments and analysis.· Background in single cells experiment (10x, flow cytometer…)· Appetite for bench work & wet lab· Appetite for challenging project· Background in Bioinformatic· Familiarity with statistical software (Prism, Spotfire, other…)· Fluent in English· Excellent written and verbal communication skills.· Experience with Recombinant AAV is a plus.· Knowledge in organoids/tissues preparation is a plus.· Experience in screening is a plus.· Background in Droplet microfluidic is optional.The Project Team:A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer and one technician.The Lab:Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina).Duration & Salary:18 months to 4 yearsLanguage:English / French (optional)References:1Pursue progress, discover extraordinaryBetter is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.Watch our and check out our Diversity Equity and Inclusion actions at !
Vitry-sur-Seine, Val-de-Marne
Fri, 28 Mar 2025 23:56:30 GMT
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