Post-doc on Acute Myeloid Leukemias chemoresistance and SUMOylation (M/F)

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Post-doc on Acute Myeloid Leukemias chemoresistance and SUMOylation (M/F)

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Job description

Offer DescriptionAcute Myeloid Leukemias (AML) are severe hematological malignancies with dismal prognosis, in particular because of high resistance to conventional chemotherapies. Our team has been interested for long in the role of SUMOylation in AML response to therapies. SUMOylation is a post-translational modification of the Ubiquitin Family, which regulates the function and fate of thousands of cellular proteins. Using various preclinical models, we have shown that the targeting SUMOylation constitutes a promising new therapeutic approach in AML (Gabellier et al, Haematologica 2024; Boulanger et al, Nucleic Acids Research 2023). For more informations: .
The aim of the project is to delineate the role of SUMOylation in AML chemoresistance, in particular through its ability to control AML cells metabolism. The candidate will also decipher the benefit of clinically relevant SUMOylation inhibitors to overcome AML chemoresistance.The candidate will use functional screens as well as genomic and proteomic approaches, including at single cell level, to study the role of SUMOylation in AML. The experiments will be carried out in AML cells lines as well as AML patient cells and different in vivo models.IGMM is a public plurithematic institute in Biology and Health Research. This Institute conducts fundamental research that is relevant to molecular and cellular medicine, with a particular emphasis on cancer and specific infectious and genetic diseases.IGMM brings together more than 220 people: researchers, technicians and students, organized into 18 research teams supported by efficient 7 technical facilities and support services. The host team is headed by Guillaume Bossis and presently includes 4 senior researchers, 3 PhD students, 2 post-docs and 1 engineer. The proposed project is funded by the INCA (National Cancer Institute) and will be carried out in close collaboration with Dr Jean-Emmanuel Sarry’s team (CRCT, Toulouse) and the clinical Hematology Department of the Montpellier Hospital.In addition to its enriching environment, the CNRS offers the following benefits:
– 44 days’ leave and RTT with the possibility of acquiring 2 days for splitting, i.e. a maximum of 46 days
– partial reimbursement of public transport costs to and from work
– possibility of benefiting from the sustainable mobility package
– reimbursement of supplementary health insurance costs up to €15 per month, subject to conditions
– low-cost on-site canteen
– parking
– leisure, sports and cultural offers via the CNRS social action and mutual aid committee (CAES) or local social action committees (CLAS)Where to apply WebsiteRequirementsResearch Field Biological sciences Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Biological sciences Years of Research Experience NoneAdditional InformationEligibility criteriaCandidate should hold a PhD degree in biological sciences. An expertise in onco-hematology, ubiquitin-like modifiers or metabolism would be appreciated although all relevant profiles will be studied. The candidate should be proficient in English.Additional commentsThe position is available starting May 1st, 2025 (flexible starting date). The initial contract is for 13 months, renewable up to 2 years. The candidates will be encouraged to apply for further funding to extend their stay. Interested applicants should send their CVs, including research interests and contact information for two references. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institut de génétique moléculaire de Montpellier Country France City MONTPELLIER GeofieldContact CityMONTPELLIER WebsiteSTATUS: EXPIREDShare this page

Expected salary

Location

Montpellier

Job date

Thu, 09 Jan 2025 06:34:17 GMT

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