Post-doctoral fellow (M/W) for the development of mutliscale super-resolved fluorescence microscopy

9 Sep 2023
Job Information

Organisation/Company

CNRS

Department

Institut des Sciences Moléculaires d’Orsay

Research Field

Physics

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

29 Sep 2023 – 23:59 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Dec 2023

Is the job funded through the EU Research Framework Programme?

HE

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The person recruited will be part of the NANOBIO team and will participate in the development of new approaches in super-resolution microscopy, combining optical development and biological applications. This position will involve developing a microscope that can be used to observe cells at different scales beyond the diffraction limit, either by applying structured excitation (SIM) in order to gain a factor of 2 in resolution, or by combining structured excitation with the localisation of single molecules (ModLoc technique patented by the team), in an original configuration. The transition from one approach to the other will be made by applying deep learning approaches, developed in collaboration with R. Henriques’ team, following training of the network depending on the state of development and expression of the cell lines. Within this European consortium, biological applications will be carried out in collaboration with the Institut Curie, and part of the instrumental/software developments will be carried out with Abbelight.
The position may be extended for a further 12 months.

The person will contribute to various aspects :
– setting up the optical elements for this new instrumental device
– testing and validation of the new experimental set-up
– pilot/simulation programming
– characterisation of various samples
– writing articles
– taking part in conferences

This work will be carried out within ISMO (Unité Mixte CNRS / Université Paris-Saclay) as part of a European EIC PAthfinder project involving 4 other laboratories and one company (Abbelight). The laboratory has an on-site culture room and various microscopes for single molecule localization microscopy, SIM and FLIM.

Requirements

Research Field

Physics

Education Level

PhD or equivalent

Languages

FRENCH

Level

Basic

Research Field

Physics

Years of Research Experience

None

Additional Information
Eligibility criteria

– optics
– microscopy
– knowledge of single-molecule imaging (acquisition and processing)
– knowledge of photophysics
– knowledge of cell culture
– python programming

Website for additional job details

https://emploi.cnrs.fr/Offres/CDD/UMR8214-SANLEV-017/Default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Institut des Sciences Moléculaires d’Orsay

Country

France

City

ORSAY

Where to apply

Website

https://emploi.cnrs.fr/Candidat/Offre/UMR8214-SANLEV-017/Candidater.aspx

Contact

City

ORSAY

Website

http://www.ismo.u-psud.fr

STATUS: EXPIRED