Postdoctoral Fellow – V Papayannopoulos lab

Job title:

Postdoctoral Fellow – V Papayannopoulos lab

Company:

Francis Crick Institute

Job description

Salary for this Role:From £41,935 with benefits, subject to skills and experienceJob Title:Postdoctoral Training Fellow – Papagyannopoulos LaboratoryReports to: Venizelos PapayannopoulosClosing Date: 23.59 GMTJob Description:Postdoctoral Fellow – V Papayannopoulos labReporting to: Venizelos Papayannopoulos, Principal Group LeaderContact term: This is a full-time, fixed term (4-year) position on Crick terms and conditions of employment.Closing date and time: The position will remain open until suitable candidates are found.The Research GroupOur lab studies how neutrophils tune their effector mechanisms such as neutrophil extracellular traps (NETs) to clear invading pathogens. We dissect the mechanisms that regulate these effector strategies and investigate how their dysregulation promotes inflammatory diseases such as atherosclerosis and colitis.We have identified a basic mechanism of NET formation that is implicated in anti-fungal defence but also promotes atherosclerosis. We have also uncovered pathways that allow neutrophils to distinguish between different pathogens such as bacteria and fungi and tune NETosis and inflammation for efficient pathogen clearance. We also showed that NETs are highly proinflammatory through their histones and regardless of their origin extracellular histones lead to a break-down of innate and adaptive immunity during sepsis. Ongoing projects in the lab range from areas of basic NET biology and regulation to the regulation of neutrophil heterogeneity and its impact on inflammatory disease through the cross-talk with other immune cells.The ProjectOver the years, we have developed a strong interest in the role of NETs in cardiovascular diseases. NET are key drivers of atherogenesis1, but the events that promote the pre-clinical stages of cardiovascular disease are still poorly understood.Defects in NET degradation are associated with autoimmunity and hight rates of mortality during severe infection such as sepsis and COVID-19 pneumonia2. In addition, NET degradation deficiencies can manifest in healthy young individuals who later in life exhibit an increased risk for cardiovascular disease2.The project will identify mechanisms that interfere with NET clearance and investigate their role in CVD development using mouse models and human samples. This ambitious project will involve significant biochemical work, complex cellular assays, mouse models of atherosclerosis and analysis of human samples. We are therefore seeking a highly motivated post doc fellow with expertise in the field of inflammation, biochemistry and mouse immunology and an established track record.Post-doctoral fellows can also develop their own projects by pursuing questions stemming from ongoing work or towards completely new directions. Other areas we are currently investigating are mechanisms of neutrophils heterogeneity communication in anti-fungal immunity and disease.Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and participate in training PhD students. The ability to work in a team is essential.References1. A Warnatsch, M Ioannou, Q Wang, V Papayannopoulos. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 349 (6245), 316-320 (2015).2. IV Aramburu, D Hoving, SI Vernardis, MCF Tin, M Ioannou, MI Temkin, … V Papayannopoulos. Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia. Immunity 55 (12), 2436-2453. (2022).Key experience and competenciesExcellent scientific written skills are necessary. The applicant should have already performed interesting and conceptually stimulating work that has resulted in a first author publication or in the process of being published.This position is funded by the laboratory’s Crick core funding, and the applicant will be encouraged to apply for fellowships.The post holder should embody and demonstrate our core Crick values:Bold; Open; CollegialEssentialPhD in immunology, infection biology, biochemistry or cell biology or in the final stages of PhD submissionGood knowledge and experience in immunology and biochemistry.Technical expertise in biochemical, cell biological and mouse work.Track record of writing papers as evidenced by publications or submitted manuscripts in referred journalsEvidence of data presentation at scientific meetingsExperience with experimental design is absolutely essentialAbility to work independently and collaborate with othersDesirableExperience in research with model biological system (mouse)Experience in myeloid cell biology, cellular signalling pathways.Experience in biochemistry and cellular biologyAbout UsAt the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.If you are interested in applying for this role, please apply via our .The closing date for applications is 2024 at 23:59All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.If you require a visa to work in the UK we will help support your application should you be successfulEquality, Diversity & InclusionWe welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:Find out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

Location

London

Job date

Wed, 06 Mar 2024 05:15:21 GMT

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