Postdoctoral Researcher (Bioinformatics) – IMol, Polish Academy of Sciences
Offer DescriptionThe International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, is a new and vibrant institute constituted in partnership with University Medical Center Göttingen, Germany and University of Warsaw, Poland. We provide innovative training, guidance and mentoring in an international “open door” environment with state-of-the-art infrastructure.Short description of the projectThe TUNIC project aims to better understand how neutrophils, the most abundant type of white blood cell, impact cancer immunotherapy. Immunotherapies like immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, but resistance remains a challenge. The TUNIC project will investigate whether neutrophils can be targeted to enhance immunotherapy efficacy.Current research on neutrophil function in cancer relies heavily on mouse models, which may not accurately reflect human biology due to significant species-specific differences in neutrophil biology. For example, human neutrophils contain antimicrobial proteins that are absent in mouse neutrophils. Reliance on mouse models has resulted in several failed clinical interventions for human diseases. Similarly, large-scale sequencing datasets, while informative, do not fully elucidate human neutrophil functionality.To overcome these limitations, the TUNIC project will utilize a “phenotype-first” approach. This involves:
The TUNIC project expects to identify novel therapeutic targets in neutrophils to boost immunotherapy efficacy in a clinically relevant setting. This research could pave the way for new treatment strategies that overcome immunotherapy resistance in cancer patients.A bit about the groupAt the Laboratory of Advanced Tumor Systems, we combine novel three-dimensional tumor models with primary tumor-derived cells to investigate the therapy-modulating behavior of hard-to-model cell types, such as human neutrophils. Using physiologically relevant systems, we also aim to examine the complex cellular interactions within the tumor microenvironment (TME), with the with the end goal of leveraging these insights to identify novel therapeutic targets for cancer.Description of the tasks of the projectThe hired postdoctoral researcher will be responsible for the establishment of the bioinformatics and spatial sequencing/proteomics analysis pipelines. This involves analysing sequencing (both transcriptomic and proteomic) data and creation and implementation of all the relevant computational tools. In addition, this position will also be responsible for the integration of live video imaging data and transcriptomics data, which will most likely require the development of novel bioinformatics tools and approaches.List of specific requirements
We offer
How to applyPlease prepare the following documents (you will be asked to submit the documents merged into one PDF file while filling out the application form):
To apply for this position, please visit the Google Forms link attached to this job offer and select the position labelled as “Postdoctoral researcher – SONATA 20 – Dr Martin Nurmik group” during your application process.Where to apply WebsiteRequirementsAdditional InformationWork Location(s)Number of offers available 1 Company/Institute The International Institute of Molecular Mechanisms Country Poland GeofieldContact WebsiteSTATUS: EXPIREDShare this page
4700 per month
Polska
Mon, 21 Jul 2025 04:02:53 GMT
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