Postdoctoral Scientist, Computational epigenomics and Genetics

Job title:

Postdoctoral Scientist, Computational epigenomics and Genetics

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Job description

Offer DescriptionThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the ‘ Award from the European Commission. This is a recognition of the Institute’s commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the and the (Charter and Code).The roleWe are seeking a motivated postdoctoral scientist to lead a project in one of these two areas:

• Analysis and discovery of rare noncoding mutations causing diabetes, using advanced statistical genetics, computational regulatory genomics, and analysis of whole genome sequences in unique patient cohorts.
• Using computational strategies to develop a high resolution epigenomic technology with translational potential.

About the labThe Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus, and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information is used to direct cell-specific gene expression, and to pinpoint gene regulatory defects underlying human disease.The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach gives us unique opportunities to engage in collaborative projects that combine experimental and computational methods. For a computational project, for example, this enables generating new datasets, and experimental testing of in silico predictions. The group is funded by European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Skłodowska-Curie Actions program, a CIBERDEM diabetes network, and a collaborative project with biotech. The lab forms part of international consortia focused on advancing research in regulatory genomics, single cell genomics, and human genetics.Recent studies from the lab include:

• A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes. (In review).
• Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes. (In review).
• Transcription regulation by long non-coding RNAs and its disease relevance (Nat Rev Mol Cell Biol, 2024).
• HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).
• Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster.(Dev Cell, 2022).
• Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).

Whom would we like to hire?Professional experienceMust Have

• You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields
• You have proven programming competence in Python, R, or C++, or related languages, and expertise in Linux and high-performance computing environments
• You have proven experience in applying statistical methods to large datasets. Familiarity with methods in machine learning and/or statistical inference is desirable but not essential
• Experience in genome sequence variant data and/or statistical genetics is highly advantageous to engage in a human variant analysis project. Experience in NGS data analysis is necessary to engage in an epigenomics technology project

Desirable but not required/ Nice to have

• A first-author publication track-record is highly advantageous
• A proven research track record in any other area of genome or epigenome data analysis is highly advantageous

Education and training

• You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields

Languages

• You are fluent in English

Competences

• You desire and have the ability to work both collaboratively and independently within a multidisciplinary environment

The Offer – Working Conditions

• Contract duration: Contract for Technical and Scientific Activities – estimated duration of 2 years, with the possibility of renewal.
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: January 2025

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the .We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.Application ProcedureAll applications must include: * A motivation letter addressed to Dr Jorge Ferrer

• A complete CV including contact details.
• Contact details of two referees.

All applications must be addressed to Dr. Jorge Ferrer and be submitted online on the CRG Career site –Selection Process

• Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
• Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
• Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by January 3rd, 2025.Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.AXA Project: 2013 – LIFE – Chair – Fundació Centre de Regulació Genòmica – FERRER Jorge “with the support of the AXA Research Fund”Where to apply WebsiteRequirementsResearch Field Biological sciences » Other Education Level PhD or equivalentLanguages ENGLISH Level ExcellentResearch Field Biological sciences » OtherAdditional InformationWork Location(s)Number of offers available 1 Company/Institute Centre for Genomic Regulation Country Spain State/Province Provincia City Barcelona Postal Code 08003 Street C/ Dr Aiguader 88Contact State/ProvinceProvincia CityBarcelona WebsiteStreetDr. Aiguader, 88 Postal Code08003 E-Mailnuria.ortiz@crg.eu Phone618613615STATUS: EXPIREDShare this page

Expected salary

Location

Barcelona

Job date

Fri, 27 Dec 2024 00:41:38 GMT

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