Pre-doc Researcher in Computational Glycobiology

Job title:

Pre-doc Researcher in Computational Glycobiology

Company:

Job description

Offer DescriptionProfessor Carme Rovira is looking for one PhD student to work in computational glycobiology. They will be applying state-of-art computational methods to model enzymatic reactions and glycan-protein interactions, developing new algorithms and applying them to the analysis of simulation data to aid drug discovery. Recent projects of the group can be found at:The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop different innovative strategies to 1) understand the diversity and structural complexity of archaeal, microalgal and viral N-glycosylation and 2) harness this knowledge for new solutions in biomedicine and biotechnology.Protein N-glycosylation, or the attachment of oligo- and polysaccharides at specific asparagine residues, is conserved throughout life, and is now observed even in the viral world. In contrast to eukaryotes, whose well-studied N-glycosylation machineries are relatively simple, archaea, microalgae and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse N-glycans, and the same holds true for some recently discovered viruses. Because protein glycosylation occurs far downstream of protein synthesis the complexity and diversity in N-glycan structures are poorly understood in detail. This holds true specifically for N-glycosylation events that are the subject of the GLYCO-N program: those in archaea, microalgae and viruses.Understanding of the how and why of N-glycosylation in these organisms will open up many possibilities ranging from drug discovery (antivirals) to biotechnology (glycoprotein and glycoprocessing enzyme engineering for materials and life sciences).The GLYCO-N network brings together a diverse group of glycobiology researchers with world-leading expertise in microbiology, (bio)organic chemistry, computational and structural biology, bioinformatics and chemical biology. The GLYCO-N DC in the group of Prof. Carme Rovira will have their own individual project and will be exposed to complementary Glycoscience in research groups and biotech companies from the GLYCO-N consortia.The group of Prof. Carme Rovira is internationally recognized for its work in computational glycobiology. The project of the GLYCO-N DC is intended to characterize computationally the carbohydrates that are attached to Asn residues in proteins and its interaction with proteins and enzymes, including binding and reactivity. The techniques/tools to be used are docking, structure and sequence alignment, molecular dynamics and ab initio MD simulations, specifically quantum mechanics/molecular mechanics (QM/MM). The work is presential and the student will be enrolled in a PhD program of the UB.Key Duties

• Conduct high-quality research
• Write manuscripts that can be published in prestigious journals
• Present your research at group meetings
• Keeping high quality and organized lab notebook and progress reports
• Collaborate with various research groups across Europe
• Help supervise MSc, undergraduate students and visitors
• Participate in meetings of the GLYCO-N consortium
• Attend courses, seminars and other training activities (upon supervisor agreement)
• Get involved in group duties

RequirementsResearch Field Chemistry Education Level Master Degree or equivalentSkills/Qualifications– A completed master’s degree in a Chemistry-related discipline by Sept 2024. Alternatively, the equivalent qualifications to be enrolled in a PhD program at UB.– Outstanding academic record– Strong motivation for scientific research in an interdisciplinary and international environment– Excellent English presentation and writing skills– Good organizational and communication skills, being a team-player– Experience in molecular dynamics simulations of proteins and enzymes, data analysis and interpretation– Experience in glycobiology– Knowledge of the Linux operating systemSpecific RequirementsAt the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in Spain for more than 12 months in the 3 years immediately prior to the reference date.Languages ENGLISH Level ExcellentAdditional InformationAdditional commentsTo apply:1) Application letter2) Curriculum vitae3) Full academic record (for both bachelor and MSc studies)4) Two recommendation letters from senior scholars that know the candidate and have interacted with him professionally. These need to be sent directly to , with the name of the applicant and the words GLYCO-N in the subject, e.g. “recommendation letter for Ms. Jane Smith (GLYCO-N)”Work Location(s)Number of offers available 1 Company/Institute Universitat de Barcelona Country Spain City Barcelona Postal Code 08028 GeofieldWhere to apply E-mailrecruitment.roviralab@gmail.comContact State/ProvinceBarcelona CityBarcelona WebsiteStreetGran Via de les Corts Catalanes, 585. Postal Code08007 E-Mailrecerca.europea@ub.educ.rovira@ub.edu Phone+34 934039254STATUS: EXPIRED

Expected salary

Location

Barcelona

Job date

Thu, 15 Feb 2024 02:09:20 GMT

To help us track our recruitment effort, please indicate in your email/cover letter where (vacanciesin.eu) you saw this job posting.