Principal Scientist

Job title:

Principal Scientist

Company:

CK Group

Job description

CK Group are recruiting for an experienced and dynamic Scientist, at either Senior/ Principal level, to join an early-stage biotechnology start-up, based in Oxford, on a permanent basis.The Company:Our client is an early-stage biotechnology start up, combining artificial intelligence (AI), and advanced high-throughput TCR screening techniques to revolutionise the treatment of solid cancers.Location:Oxford.The Role:To lead the in vivo and in vitro validation of T-cell engagers, and help drive forward the development of TCR engineering and processes.Responsibilities:

• To perform high-throughput TCR display methods by purifying recombinant TCRs.
• Carry out protein characterisation (expression, purification and biophysical analysis).
• Design and characterise TCRs for disease targets.
• Oversee lab protocols and technical documents.
• To be hands-on in the lab and manage tissue culture preparations.
• Skills in data analysis (using software R) for Next Gen Sequencing analysis – desirable.

Your Background:

• PhD qualified (biochemistry, immunology, cell biology) plus strong laboratory experience (academia and industry).
• Experience in in vivo and in vitro validation of T-cell engagers (TCEs).
• Experience in Investigational New Drug (IND-enabling/ approval) – ESSENTIAL.
• Expertise in cell and immunological assays (flow cytometry, ELISA) with knowledge around cloning and PCR.
• Strong background in protein characterisation and biophysical characterisation.

Benefits:Competitive salary, option for home working (as per project demands), stock options.Apply:It is essential that applicants hold entitlement to work in the UK. Please quote job reference 141 244 in all correspondence.If this position isn’t suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news.INDCP

Expected salary

£50000 – 60000 per year

Location

Oxford

Job date

Wed, 02 Jul 2025 22:26:52 GMT

To help us track our recruitment effort, please indicate in your email/cover letter where (vacanciesin.eu) you saw this job posting.