Research Fellow

Job title:

Research Fellow

Company:

University College London

Job description

About usThe UCL Cancer Institute is the hub for cancer research at University College London, one of the World’s leading universities. The Institute draws together over 400 talented scientists who are working together to translate research discoveries into developing kinder, more effective therapies for cancer patients. In particular, it fosters links between basic cancer researchers across Biomedicine and with the clinical activities of our four partner hospital trusts, known as UCL Partners (University College London Hospital NHS Foundation Trust, Great Ormond Street Hospital for Children NHS Trust, the Royal Free Hampstead NHS Trust, and Moorfields Eye Hospital NHS Foundation Trust), as well as the London School of Pharmacy and Cancer Research UK. The Institute has greater clinical links than any comparable centre in the UK, creating a unique opportunity for significant impact on the delivery of clinical service to cancer patients.The UCL Cancer Institute is part of the CRUK City of London Centre, which draws together the expertise present in four leading centres for cancer research, UCL, Barts, KCL and the Francis Crick Institute.Further Information about the UCL Cancer Institute can be found on our website .About the roleOsteosarcoma ResearchWe are seeking a collaborative and self-motivated postdoctoral scientist, to work on an exciting new project to investigate mechanisms of chemoresistance in osteosarcoma as part of the major osteosarcoma research initiative in UCL Cancer Institute.Sarcoma is a rare cancer and represents about 2% of all cancers. Osteosarcoma represents the most common primary bone cancer and commonly occurs in children and young people. While significant advances have been made in the treatment of other metastatic cancers through chemotherapies and immunotherapies, osteosarcomas usually do not respond well to these treatments.The best prediction to survival of this disease is the response to chemotherapy, however it is not possible to predict which patients will respond to this toxic treatment and who will not. Roughly 50-60% of patients survive 5 years, dropping to 33% for 10 years and just 10% for 20 years.The main aims of this program are: * To understand the mechanisms by which genetic / epigenetic alterations drive resistance to chemotherapy

• To identify novel immunotherapy targets and approaches
• To uncover and test novel therapeutic strategies.

The post is funded by the Little Princess Trust for 6 months in the first instance, with potential to extend to 2.5 years. A start date as soon as possible is preferred.PhD students who are in the last months of their project are also encouraged to apply but should indicate in their application when they can join the group.Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.Applications should include a CV and a Cover Letter: In the Cover Letter please evidence the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the ‘Why you have applied for this role’ field in the application form, which is limited in the number of characters it will allow.)About youA PhD (or close to completion) and higher degree, with relevant laboratory experience or an MSc in Cancer Biology or a related discipline is essential.The successful candidate will be highly motivated, passionate about research in the biomedical field and will have substantial experience in a broad range of cell culture and molecular biology. Experience in computational biology (trascriptomics) is desirable.The candidate is required to have a higher degree in a relevant subject, excellent practical cell biology skills and experience, as well as a strong theoretical understanding of cancer biology. The candidate is also required to have excellent attention to detail and to have a flexible and cooperative approach to working with others, as well as having an analytical approach to problem solving.The candidate should possess the ability to work both as a team member and independently under minimal supervision. In addition, the candidate should have broad experience in establishing and optimising new assays and providing technical support to other lab members (PhD students and technicians).What we offerAs well as the exciting opportunities this role presents we also offer some great benefits some of which are below:

• 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days)
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

For rewards and benefits at UCL please visit: .Our commitment to Equality, Diversity and InclusionAs London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.You can read more about our commitment to Equality, Diversity and Inclusion here:Available documents

Expected salary

Location

North West London

Job date

Thu, 05 Jun 2025 02:32:42 GMT

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