Research Fellow in Quantitative Interaction Proteomics and Chemoproteomics

The School of Biological Sciences at Queen’s University Belfast, is currently seeking to recruit a talented Research Fellow in Quantitative Interaction Proteomics and Chemoproteomics.

An experienced and motivated postdoctoral scientist is sought to join the Collins Lab (https://collinslab.net/ ) in the School of Biological Sciences at Queen’s University Belfast. The successful candidate will undertake a senior role in the planning and delivery of research activity focused on quantitative interaction proteomics and data independent acquisition (DIA) mass spectrometry.

Our research group focuses on (i) development of new methodology in DIA mass spectrometry1,2 , (ii) methods to characterize dynamic reorganization of protein complexes/interactions using both targeted and global approaches3,4 , and most recently (iii) the application of these methods in chemical biology and drug discovery, and (iv) the application of these methods to problems in various disease settings including innate immunity, cancer, and host-pathogen interactions. This role will focus on the development and application of strategies to quantify protein complex reorganization in signalling systems. This will include of neo protein-protein interactions by chemical induced proximity relevant in the context of early-stage drug discovery.

The successful candidate will have a demonstrated track record in mass spectrometry-based proteomics research with an excellent PhD degree awarded and strong publication record. The successful applicants will have responsibilities in independent research, supervision, planning, day-to-day lab management, collaborations, and outreach. The role will include access to newly established capability within the new Chemoproteomics Centre of Excellence situated within QUB (https://bit.ly/chemoprot ).

References: 1 Meier, F. et al.Nature Methods 17, 1229 (2020) 2 Collins, B. C. et al.Nature Communications 8, 291 (2017) 3 Collins, B. C. et al.Nat Meth 10, 1246 (2013) 4 Heusel, M. et al.Cell Systems 10, 133 (2020).

The successful candidate must have, and your application should clearly demonstrate that you meet the following criteria:

Have or about to obtain* a PhD in quantitative proteomics, mass spectrometry, or a related discipline. (* within 3 months of commencement of post).

Substantial relevant research experience in developing and applying mass spectrometry-based quantitative proteomics methods.

Peer reviewed publications or preprints in the area of mass spectrometry-based proteomics.

Experience in the general maintenance and technical troubleshooting of mass spectrometry instruments.

Experience in sample preparation and separations for mass spectrometry-based proteomics.

Practical experience in processing, recording and handling data sets, and performing statistical analysis.

Strong publication record in peer reviewed journals.

Experience with data analysis using scripting (e.g. R, python, unix).

Please note the above are not an exhaustive list. For further information about the role including the essential and desirable criteria please click on the Candidate Information.

This is a fixed term post available for 21 months (expected start by 1 June 2024. Fixed term contract posts are available for the stated period in the first instance but in particular circumstances may be renewed or made permanent subject to availability of funding.

At Queen’s our people are at the heart of everything we do. As a staff member you will become part of a vibrant organisational culture, which will provide you with the opportunity to achieve your full potential and enhance your career through a continuous focus on learning and development.

We offer an excellent employment package that includes:

• Great terms & conditions
• Pension schemes
• Flexible working by enabling you to design your working week in collaboration with your manager through a blend of remote and office working
• Family-friendly initiatives
• Career development opportunities
• Support for health & mental wellbeing
• Generous holiday entitlement of 8.4 weeks a year (made up of 23 days annual leave, 10 closure days and 9 bank holidays)

Queen’s University is committed to promoting equality of opportunity to all. We have created an inclusive culture by establishing staff networks such as iRise (Black, Asian, Minority Ethnic and International Staff Network) and PRISM (LGBTQ+) which help us progress equality.

We also subscribe to Equality Charter Marks such as the Diversity Charter Mark NI in addition to Athena Swan. For further information on our commitment to Equality, Diversity and Inclusion, please visit:  www.qub.ac.uk/diversity ; www.qub.ac.uk/qgi  and www.qub.ac.uk/sites/StaffGateway/StaffNetworks/

Informal enquiries may be directed to Mohammad Arefian at [email protected]

Candidate Information

About the School

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Information for International Applicants