STUDY OF BIOACTIVE PROPERTIES (MICROBIOME) BY METABOLOMIC & DNA NON-TARGET SCREENING OF THE THERMAL WATERS AND AROMATIC PLANTS OF THE POCTEFA TERRITORY ON THE SKIN

Université de Pau et des Pays de l'Adour

vacanciesin.eu


9 Feb 2024
Job Information

Organisation/Company
Université de Pau et des Pays de l’Adour
Department
IPREM (CNRS-UPPA UMR5254)
Research Field
Chemistry » Analytical chemistry
Biological sciences » Biology
Biological sciences » Biodiversity
Researcher Profile
Recognised Researcher (R2)
Country
France
Application Deadline
3 May 2024 – 17:00 (Europe/Brussels)
Type of Contract
Temporary
Job Status
Full-time
Is the job funded through the EU Research Framework Programme?
Interreg
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

CONTEXT – SCIENTIFC FRAMEWORK

This research study will be developed as part of the CARUSO project: “Cooperation and transfer
to valorize the natural resources and thermal waters of the POCTEFA territory: development of
cosmetic products to improve the microbiota of the skin”. Faced with the challenge of
promoting economic and social sustainability in rural areas through innovation, the CARUSO
project aims to transfer the knowledge generated to local companies (SPAs and Cosmetic
Companies), so that they can develop more innovative and sustainable Dermocosmetics
that promote the revitalisation of the territory.
The POCTEFA “CARUSO” (ref. EFA085/01) which has recently been granted to UPPA (Pau) &
UNIZAR (Zaragoza), aims at bringing Metabolome and Microbiome from bio-sourced and local
thermal waters and natural product extracts in a new generation of more sustainable cosmetics.
The covered territory comprises the bordering regions of Spain, France and Andorra. From these
territories emanate numerous thermal springs with well-known therapeutic properties for the
skin. However, the microbiota and metabolites present in these thermal waters, as well as their
possible effects on skin health or dermal microbiota, are completely unknown. On the other hand,
in the POCTEFA territory, some medicinal aromatic plants, such as rockrose, marigold, sage or
lemon balm, are commonly used for the production of natural cosmetics due to their beneficial
properties for the skin.
The combination of thermal waters with natural plant extracts can be an innovative strategy for
the development of new sustainable and ecological cosmetics, with new therapeutic targets that
improve the health of the skin and its dermal microbiota.
The results will be communicated in international open access scientific journals and at national
and international congresses. The dissemination of the results will be carried out through social
networks, radio or dissemination conferences, through informative articles, press releases,
interviews or talks, organized as part of the communication and dissemination plan of the
CARUSO project. 

 

MISSION – MAIN ACTIVITIES & MISSIONS

Given the interest in the use of thermal waters and medicinal aromatic plant extracts for the generation of natural and innovative cosmetics, the general objective of this project is to evaluate the bioactive properties of several thermal waters and natural plant extracts from the POCTEFA territory, as well as the combination of both, on the health of the skin. The specific objectives are the following:
1.Characterize the microbiota and metabolites present in the thermal waters.
2.Evaluate the effects of thermal waters on skin health.
3.Study the effects of various aromatic/medicinal plants on skin health.
4.Determine the combinations of thermal waters with natural plant extracts that are mosteffective in improving skin health.

 

POSITION AND ASSIGNMENTS

The position has its focus on the characterization and the valorization of local resources. The successful candidate will contribute to the tasks and methodology proposed to meet the specific objectives are as follows:
Objective 1. Characterize the microbiota and metabolites present in thermal waters.
1.1. Collection of samples of thermal waters. Methodology: Water samples will be collected from 2 Spanish spas and 6 French spas, at 4 different points and at 4 different times of the year and in triplicate.
1.2. Characterization of the microbiota of thermal waters. Methodology: Metagenomic studies and bioinformatic analysis to determine the microbial diversity and composition.
1.3. Characterization of metabolites in thermal waters. Methodology: Non-Target Screening by UHPLC-timsTOF HRMS and ICPMultiQuadMSMS, Metabolomic, Lipidomic “in silico” Database, with the synergy between Machine Learning and Artificial Intelligence for big data analysis to determine the metabolites and elements fingerprint.
Objective 2. Study the extracts of various local aromatic/medicinal plants.
2.1. Collection of sample extracts. Methodology: Water samples will be collected from 2 Spanish spas and 6 French spas, at 4 different points and at 4 different times of the year and in triplicate.
2.2. Characterization of the active components relative to the effects of natural extracts from aromatic/medicinal plants on skin. Methodology: The biological effects of 8-10 natural extracts from 4 different plants (rockrose, lemon balm, marigold and sage) previously selected will be evaluated. The correlation between clinic study with a molecular identification of the involved key molecules with an adequate data mining will be made on cells mode in parallel than timsTOF-HRMS screening
Objective 3. Determine the combinations of thermal waters with natural plant extracts that are most effective in improving skin health.
3.1. Evaluation of the synergistic effects of natural extracts of aromatic/medicinal plants and thermal waters on the skin. Methodology: The 4 thermal waters and the 2 natural plant extracts with the best bioactivity on the skin will be selected and each thermal water will be combined with 1 or 2 of the selected natural extracts to evaluate the synergistic effects. Thus, the 8 possible combinations will be tested in the same cellular models and with the same tests as described in task 2.2, a total of 63 tests per combination.

 

Requirements

Research Field
Chemistry » Analytical chemistry
Education Level
PhD or equivalent

Research Field
Biological sciences » Biodiversity
Education Level
PhD or equivalent

Skills/Qualifications

Priority will be given to candidates holding a PhD degree in Biology, BioChemistry or Analytical Chemistry as major. The candidate should be interested in the biomolecule’s characterization, mass spectrometry, bioinformatic, statistics and DNA sequencing of natural products, microorganisms, cell extracts or waters.
Extensive experience in experimental research in molecular and biomolecular chemistry, structure-activity relationships, characterization of unknow metabolites is desirable.

The applicant must be proficient in spoken and written English. French knowledge would be desirable, but non-mandatory. The ranking will also accord weight to the candidates’ assessed competence in their ability to interact and communicate effectively in a multi-disciplinary and multi-national research environment.

Specific Requirements

APPLICATION – EVALUATION CRITERIA

Candidates will first be selected based on their application file (Dead line 3rd May 2024). Those selected after this first step, will then be interviewed, by visioconference (Teams; Zoom) by Dr C. Cravo-Laureau & Dr H. Preud’homme. Application files will be evaluated based on the following criteria:
• Appropriate education and work/research in related fields.
• English language proficiency
• Candidate’s ability to present her/his work and results
• Candidate’s motivation, knowledge, scientific maturity, and curiosity.
• Emphasis will also be placed on personal skills.
• Work experience in a laboratory – or likewise; previously achieved research work(reports, publications).

Selections will be made regardless of gender, nationality, religion, ethnicity, and cultural background.

Application will include: (in a single pdf file)
• CV
• Cover letter
• Master’s degree grade transcripts and ranking
• 2 Reference letters
• Contact details of at least two people, from you work environment, who can becontacted for further reference

Additional Information
Selection process

Candidates will first be selected based on their application file (Dead line 3rd May 2024). Those selected after this first step, will then be interviewed, by visioconference (Teams; Zoom) by Dr C. Cravo-Laureau & Dr H. Preud’homme. Application files will be evaluated based on the following criteria:
• Appropriate education and work/research in related fields.
• English language proficiency
• Candidate’s ability to present her/his work and results
• Candidate’s motivation, knowledge, scientific maturity, and curiosity.
• Emphasis will also be placed on personal skills.
• Work experience in a laboratory – or likewise; previously achieved research work(reports, publications).

Selections will be made regardless of gender, nationality, religion, ethnicity, and cultural background.

Application will include: (in a single pdf file)
• CV
• Cover letter
• Master’s degree grade transcripts and ranking
• 2 Reference letters
• Contact details of at least two people, from you work environment, who can becontacted for further reference

Work Location(s)

Number of offers available
1
Company/Institute
IPREM
Country
France
Geofield

Where to apply

E-mail
[email protected]

Contact

City
Pau
Website
http://iprem.univ-pau.fr/live/
Street
2 av. Présdient Angot
Postal Code
64053
E-Mail
[email protected]
[email protected]

STATUS: EXPIRED

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