Thesis on biocidal and micro-structured polymer surfaces for antimicrobial applications in hospitals (M/F)

CNRS

vacanciesin.eu


6 Jan 2024
Job Information

Organisation/Company
CNRS
Department
Institut de Chimie et des Matériaux Paris-Est
Research Field
Chemistry » Physical chemistry
Physics » Chemical physics
Physics » Biophysics
Researcher Profile
First Stage Researcher (R1)
Country
France
Application Deadline
26 Jan 2024 – 23:59 (UTC)
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
35
Offer Starting Date
1 Mar 2024
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

The thesis work will be carried out at the Institut de Chimie et des Matériaux Paris-Est (ICMPE UMR 7182 CNRS-Université Paris-Est Créteil) in the “Chimie Moléculaire et Matériaux Macromoléculaires” (C3M) department. ICMPE was created on January 1, 2007 on the CNRS campus in Thiais. The C3M department’s scientific activities cover the various fields of polymer science and engineering from macromolecular synthesis to polymer processing, including the physical chemistry of polymers in solution and polymer interfaces, and the physics of colloids and solid-state polymers. More specifically, the thesis will be carried out in the Biomacromolecules and Sustainable Materials (BioM&M’s) scientific group. Experiments will also be carried out at Université Paris-Est Créteil (UPEC) and Université d’Orsay.

Project timetable and candidate profile:
The doctoral project will begin in January 2024 for a period of 36 months, shared between ICMPE and ISMO depending on how the project develops.

Applicants must have completed a course of study in chemistry, polymer science or materials science, and must have obtained an engineering degree or a Master 2 (graduation by the end of September 2023 at the latest). Knowledge of organic synthesis, polymer chemistry, materials science and possibly photochemistry is highly desirable. They must also have good communication and writing skills in English. French and/or English are not compulsory, but fluency in either of these languages may be an advantage.

Candidates must submit the following documents:
– Curriculum Vitae (English or French)
– Letter of motivation (English or French)
– Letter of support from a professor at your engineering school or university
– Grades obtained in Master 2

Selected candidates will be interviewed in French. Incomplete applications will not be considered.

The aim of this thesis is to design original biocide surfaces combining photo-stimulable biosourced polymers (generating reactive oxygen species, ROS) and a 2-photon 3D photo-printing strategy. We suggest to design 3D-microstructured coatings on plastic/metal/silicone/glass surfaces used by hospital staff and patients. These 3D materials will be synthesized from biosourced monomers and dyes capable of locally generating ROS under visible light exposure. Porphyrin, eosin or polyphenol derivatives will be used because of their high absorption coefficients in the visible range, and their very high ROS production quantum yields under visible-light irradiation. The rapid amplification of the concentration of ROS produced within these µ-volumes will result in a highly virulent and rapid biocidal effect. We’ll be developing micro-structured, reusable antibacterial coatings for rapid, non-toxic disinfection in a very short time. E. coli, S. aureus and P. aeruginosa will be used as models and as well as various multi-resistant strains present at Henri Mondor Hospital to evaluate the antibacterial properties of our microstructured surfaces. In addition, the photostability of the dyes under irradiation and the mechanical and adhesion properties of the microstructures will be the key parameters to study.
The main advances of this project concern 1) the use of an innovative methodology, 2-photon 3D photoprinting, for the synthesis of µ-structures (triangles, honeycombs, cylinders, squares) of various sizes (ranging from 10 to 50 micrometers (length/height)) on different substrates (plastic/metal/silicone/glass) for bacterial entrapment; 2) spatial confinement amplifies antibacterial virulence; 3) the use of novel dyes as two-photon photoinitiators for the synthesis of 3D microstructures from non-toxic, biobased monomers; 4) in situ production of biocidal ROS responsible for the death of all types of bacteria (ROS are produced by irradiation of the dyes embedded in the 3D microstructures), 5) long-term antibacterial properties for different surfaces, while being reusable and 6) rapid disinfection of surfaces under visible light irradiation.

Requirements

Research Field
Chemistry
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Chemistry » Physical chemistry
Years of Research Experience
None

Research Field
Physics » Chemical physics
Years of Research Experience
None

Research Field
Physics » Biophysics
Years of Research Experience
None

Additional Information
Additional comments

This position is located in a sector covered by the protection of scientific and technical potential (PPST) and therefore requires, in accordance with the regulations, that your arrival be authorized by the competent authority of the MESR

Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR7182-DAVVER-003/Default.aspx

Work Location(s)

Number of offers available
1
Company/Institute
Institut de Chimie et des Matériaux Paris-Est
Country
France
City
THIAIS
Geofield

Where to apply

Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7182-DAVVER-003/Candidater.aspx

Contact

City
THIAIS

STATUS: EXPIRED

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