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Structural Mass Spectrometry Scientist

University of Leeds

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As a structural mass spectrometry scientist, you will support the range of mass spectrometry modalities that are available in the facility, including hydrogen-deuterium exchange, native MS, intact protein mass measurement, proteomics and metabolomics. You will provide an efficient analytical service for users of the Facility, performing analyses for users, give advice to others regarding sample preparation, experimental design and data interpretation, actively establish internal and external links with other research groups and industrial partners, develop new techniques for biomolecular analysis, write technical summaries and project reports, maintain the mass spectrometry and chromatography equipment in good working order, and perform other general laboratory duties.

As a Structural Mass Spectrometry Scientist your main duties will include:

  • Leading the design and execution of research programs using the Facility’s hydrogen-deuterium exchange-MS, native-MS, proteomics and metabolomics [FS1] platforms;
  • Designing experimental and data analysis workflows to be applied to cutting-edge research programmes using advanced mass spectrometry techniques;
  • Develop new techniques for biomolecular analysis, in collaboration with academic staff and facility users, e.g. sample preparation, purification and analysis, including chromatographic methodology and ion mobility, and by developing hybrid solutions combining different MS approaches;
  • Using your in-depth understanding of the structural MS toolbox of approaches available for optimising sample preparation and methods to obtain data of the highest quality; 
  • Working in close collaboration with the academic leads of the Facility, Prof. Frank Sobott and Dr Anton Calabrese, and colleagues from the University of Leeds and external industrial users, having responsibility for their user experience; 
  • Developing data processing pipelines to support the research community, including liaising with IT; 
  • Taking the lead communicating research results using written reports, data/figures for publications or grant applications, presentations and conducting regular progress meetings with external/internal customers; 
  • Development, production and delivery of training programs and material for researchers at all experience levels; 
  • Playing a principle role in maintenance and troubleshooting of highly specialist equipment, working closely with field service engineers to maximise instrument operation time; 
  • Contributing to a world-class, collaborative research environment, including mentoring junior researchers, and maintaining your own continuing professional development, particularly keeping up-to-date with technology relevant to structural mass spectrometry. 

These duties provide a framework for the role and should not be regarded as a definitive list. Other reasonable duties may be required consistent with the grade of the post.

To explore the post further or for any queries you may have, please contact:

Prof. Frank Sobott , Chair in Biomolecular Mass Spectrometry

Email: [email protected]

Dr. Anton Calabrese , Sir Henry Dale Fellow & University Academic Fellow

Email: [email protected]  

Location:  Leeds – Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  Biological Sciences Faculty Offices
Category:  Technical Support
Grade: 
Grade 7
Salary: 
£37,099 to £44,263
per annum
Working Time:  100%
Post Type: 
Full Time
Contract Type:  Ongoing
Release Date:  Friday 15 March 2024
Closing Date:  Friday 12 April 2024
Interview Date: 
To be confirmed
Reference:  FBSFO1203
Downloads:  Candidate Brief

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