Job title:
3 years PhD position − Engineering of bacterial nanomachines
Company:
Job description
Offer Description3 years PhD contract (Inserm) funded by the ANR.As part of the application process, first contact Dr. Thibaud Renault (CV + motivation) for pre-approval, then you will have to register on ADUM to submit your complete application ( )BIOENGINEERING OF BACTERIAL NANOMACHINES FOR RECOMBINANT PROTEIN PRODUCTIONBacterial nanomachines are fascinating supramolecular structures capable of auto-assembly to achieve complex cellular functions. They are also critical for the virulence of many pathogenic bacteria. Type-III secretion systems (T3SS) enable the assembly of two homologous nanomachines: the bacterial flagellum and the injectisome. This process, relies on a protein complex called the export apparatus to coordinate the highly ordered assembly of tens of different substrates, which are recognized and injected at high speed across the bacterial cell envelope.
This high speed and versatile secretion process can be harnessed for biotechnological purposes. By engineering the bacteria, it is possible to drive the specific secretion of exogenous recombinant proteins. In the laboratory, we have identified and modified natural substrates to be excellent drivers of exogenous proteins secretion with expected industrial and medical applications.
The proposed research project will have both fundamental and applied perspectives. We will aim at deciphering some of the basic mechanisms of type-III secretion, in particular related to the recognition and efficiency of secretion of natural and artificial substrates.
Furthermore, we will engineer the genetic background of the bacteria and the secretion nanomachines to develop candidate biotechnological applications.
The project will involve mutually reinforcing experimental approaches (biochemistry, bacterial genetics…).RequirementsResearch Field Biological sciences Education Level Master Degree or equivalentLanguages ENGLISH Level GoodLanguages FRENCHResearch Field Biological sciencesAdditional InformationWork Location(s)Number of offers available 1 Company/Institute ARNA laboratory (Inserm U1212) Country France City Bordeaux GeofieldWhere to apply E-mail[email protected]Contact CityTalence WebsiteStreet351 cours de la Libération Postal Code33405STATUS: EXPIRED
Expected salary
Location
Bordeaux, Gironde
Job date
Wed, 01 May 2024 01:46:49 GMT
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