Asymmetric Synthesis of sulfinamidines (CDD Chercheur M/F in Organic Synthesis)

12 Mar 2024
Job Information

Organisation/Company

CNRS

Department

Institut de Chimie des Substances Naturelles

Research Field

Chemistry
Environmental science

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

1 Apr 2024 – 23:59 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Jun 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The synthesis of bioactive compounds bearing unconventional functional groups and pharmacophores is a strategic task for pharmaceutical companies. In this context, the access to aza-analogues of sulfur derivatives is a great opportunity to obtain improved drug properties in terms of solubility, activity, target selectivity as well as patents expansion. The preparation of chiral optically active sulfinamidines represents a highly valuable synthetic challenge, allowing the access to an unexplored chemical space. The enantioselective synthesis of such derivatives would allow for assessing their configurational stability in various chemical environments. In the SulFourN2 project, we will unlock the access to enantiopure sulfinamidines. As part of an ANR project, a postdoctoral research position in organic chemistry is available to study an approach to enantiomerically pure sulfinamidines based on catalytic asymmetric nitrene transfers.

– Organic synthesis and development of catalytic methods. – Choosing appropriate synthesis techniques; developing procedures and operating methods – Validating data and interpreting results – Carrying out routine characterisation of products – Dissemination of results – Training and providing information on the risks associated with techniques and products.

This project is part of a collaboration between the ICSN and the University of Grenoble-Alpes. The successful candidate will be based at the Institut de Chimie des Substances Naturelles. The ICSN is a CNRS research unit specialising in chemistry and biology. It is part of the Université Paris-Saclay, which since 2015 has brought together research and teaching establishments in the south of Paris. The ICSN is located on the Gif-sur-Yvette campus and has a staff of around 125, including 60 permanent employees working in 3 buildings. Within the “Organic Synthesis and Catalytic Methods” department, the successful candidate will join the “Organometallic Catalysis and Synthesis of Functional Molecules” team, which consists of 2 researchers, 1 postdoctoral fellow and 2 CDD/doctoral candidates. He/she will report to the team leader. He/she will work directly with the team leader and in collaboration with the other members of the team.

Requirements

Research Field

Chemistry

Education Level

PhD or equivalent

Research Field

Environmental science

Education Level

PhD or equivalent

Languages

FRENCH

Level

Basic

Research Field

Chemistry

Years of Research Experience

1 – 4

Research Field

Environmental science

Years of Research Experience

1 – 4

Additional Information
Eligibility criteria

Solid training in organic and organometallic chemistry – Experience in catalysis, possibly asymmetric -Classic analysis techniques in organic synthesis (TLC, NMR, HRMS, IR, etc.) – Use of bibliographic research tools – Work independently – Work in a team on a collaborative project, and in a multicultural environment – Respect for health and safety rules

Website for additional job details

https://emploi.cnrs.fr/Offres/CDD/UPR2301-PHIDAU-005/Default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Institut de Chimie des Substances Naturelles

Country

France

City

GIF SUR YVETTE

Geofield

Where to apply

Website

https://emploi.cnrs.fr/Candidat/Offre/UPR2301-PHIDAU-005/Candidater.aspx

Contact

City

GIF SUR YVETTE

Website

https://icsn.cnrs.fr

STATUS: EXPIRED