Biomedical Innovation for Facial Bone reconstruction in oncology

Job title:

Biomedical Innovation for Facial Bone reconstruction in oncology

Company:

Job description

Offer DescriptionThe BIOFACE project, led by Professor Dupret-Bories (Toulouse University Hospital), is one of 16 national winners of the 6th call for university hospital health research projects (RHU6). This €13m project has been awarded over €4.3m.The 5-year project covers everything from in silico research to clinical trials. Seven partners are involved in the project, including academic partners (CIRIMAT, Inserm Unit 1121), industrial partners (CERHUM, Materialise, Spartha Medical, OCR) and hospital partners (Toulouse University Hospital).Keywords: Maxillofacial reconstruction; 3D printing; biomaterial; oncology; head cancer; synthetic bone graft; hydroxyapatite, titanium, personalized implant; biocompatibility; custom-made; healing;Background: Surgery is the optimal treatment for Head and Neck cancers (HCC) and frequently requires removal of a facial bone. To limit aesthetic and functional after-effects, a bone reconstruction is performed in the same operation. The current standard use of autologous bone taken from a donor site (e.g., fibula or scapula) and revascularized by microsurgery is unsatisfactory (surgeries are long, morbid, with complications, aesthetic and motricity sequelae, and significant risks of failure (around 10%). These major surgeries are not accessible to all patients.Objectives and means: The BIOFACE project aims to develop an innovative solution based on preliminary data established by the partners to solve a clinical problem for which current solutions are suboptimal: immediate and customized one-stage bone reconstruction for HCC, while limiting morbidity. The complementary assets and competencies of each partner will allow to go from in vitro to clinical practice in 60 months. Success of BIOFACE will allow between 1.300 and 2.000 patients per year in France to avoid risk of severe aesthetic and morbid sequelae. It will also extend the scope of eligible patients. The objective of BIOFACE is to transform the surgical procedure for facial bone reconstruction and dramatically improve patients’ quality of life through:– The development of an innovative 3D printing CERHUM implant technology based on hydroxyapatite integrated with the 3D printing MATERIALISE titanium technology to obtain the design and mechanical properties necessary for jaw and maxillary reconstructions.– The development of an innovative association between a new antibacterial spray targeted at bacteria known in HCC and a healing membrane for the interface between the biomaterial (Hydroxyapatite and Titanium) and the surrounding tissues.– The validation of the bio-integration capacities despite external radiotherapy (pre-clinical and clinical trials).– The validation of the positive medico-economic impact of the BIOFACE operating procedure based on these innovative medical devices (MD).BIOFACE will also transform pre-clinical trials, using a novel “One Health approach”.Impact: BIOFACE will improve patients’ quality of life and avoid severe aesthetic and morbid sequalae. The project will reduce these costly sequalae and risk failure.By providing pioneering research programs based on One Health/One Medicine approachesAs part of this thesis, we are offering you the opportunity to work on the pre-clinical phase of the BIOFACE project, i.e. improving MDs in collaboration with industrial partners, academic partners including CIRIMAT and clinicians. The objective of this thesis will be to: (i) characterize the objects printed in 3D, including the surface properties and (ii) study the functionalization of existing MDs, particularly antimicrobial, with all partners including manufacturers (iii ) to optimize the assembly and use of DMs. You will take part in in vivo experiments on a small group of animals (subcutaneous implantation) in conjunction with a Master 2 student surgeon, and you will take part in the pre-clinical trial to treat pets with CTC (One Health solution).The student will have to promote the results by writing scientific articles and communicating.To understand what is at stake in this thesis, you will carry out a short observation period at the Toulouse University Hospital (IUCT-Oncopole) in the cervico-facial cancer surgery department. To carry out the in vivo trials, you will undergo training to obtain approval for animal experimentation (applicator).Host laboratories: The thesis will be carried out within the Phosphate Pharmacotechnie Biomateriaux team of CIRIMAT in ToulouseThesis funding: 3-year fixed-term contract – Gross monthly salary: 2100 € eurosThesis start date: October 1st, 2024Funding category: Financement public/privé
RHU ( ANR + france 2030 )
PHD title: Doctorat de Sciences et génie des matériaux
PHD Country: FranceRequirementsSpecific RequirementsCandidate profile: The candidate must have or be in the process of completing a Master 2 research and/or engineering degree in the field(s) of Materials Science or Chemistry. He/she must have skills in inorganic synthesis, physico-chemical characterizations and shapping processes. Knowledge of materials for healthcare would be an additional asset. The candidate must be open-minded, enjoy experimental work and be able to work as part of a team. Excellent oral and written communication skills (in English or French) are necessary.Additional InformationWork Location(s)Number of offers available 1 Company/Institute CIRIMAT Country France City Toulouse GeofieldWhere to apply WebsiteContact WebsiteSTATUS: EXPIRED

Expected salary

€2100 per month

Location

Toulouse

Job date

Mon, 22 Apr 2024 06:13:18 GMT

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