Pd-Catalyzed decarboxylative generation of 1,4-dipoles

2 Mar 2024
Job Information

Organisation/Company

LSO Ecole Polytechnique

Research Field

Chemistry

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)

Country

France

Application Deadline

14 Apr 2024 – 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Nitrogen‑containing heterocycles display better interactions with biological targets and therefore are prone to be effective pharmacological agents [1]. In our research group, we focus on the development of original transformations relying on cycloaddition strategies towards the rapid construction of azacycles. [2]

In this context, this project aims to investigate the reactivity of readily available precursors of 1,4 nitrogenated zwitterionic dipoles via a palladium-catalyzed decarboxylative process. These transient species will be engaged in (4+2) cycloadditions to furnish six-membered heterocycles. This underexploited strategy will allow to control the regio- and diastereoselective outcome of the transformation through a screening of the palladium ligands. Chiral ligands will also be examined to access enantioenriched structures.

 

1) Njardarson et al. J. Chem. Ed. 2010, 87, 1348

2) Anaïs Scuiller, Nicolas Casaretto, and Alexis Archambeau, J. Org. Chem. 2023, 88, 9941−9945.

Antoine Roblin, Nicolas Casaretto, and Alexis Archambeau, Org. Lett. 2023, 25, 6453−6458

 

Funding category: Contrat doctoral

PHD title: Doctorat de Chimie
PHD Country: France

Requirements
Specific Requirements

The applicant must have a strong background in the field of organic chemistry, organometallic catalysis and knowledge of good laboratory practice.

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

LSO Ecole Polytechnique

Country

France

City

palaiseau

Geofield

Where to apply

Website

https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/120811

Contact

Website

http://lso.polytechnique.fr/research-groups/alexis-archambeau/

STATUS: EXPIRED