Job title:
Post-doctoral position – Recruitment No 12/2025
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Job description
Offer DescriptionPost-doc position available in the Institute of Physical Chemistry PAS within National Science Center (NSC) OPUS 27 Project no 2024/53/B/ST4/01213 Entitled “Effect of lipid nanoparticles on the nanostructure of cell cytoplasm” Leader Dr inż. Karina Kwapiszewska Lipid nanoparticles (LNPs) are crucial for delivering nucleic acids into cells, powering mRNA vaccines and gene editing. While generally considered low-toxic (
24h), we observed significant intracellular nanostructure remodeling and diffusion hindrance within 4 hours of LNP exposure. Using Fluorescence Correlation Spectroscopy (FCS), we found these disturbances far exceed those from other stressors. We hypothesize that LNP lipids interact with cell membranes, causing this remodeling, potentially impacting organelle health and cellular stress. This project will use a soft matter approach and highthroughput biochemical assays, to analyze LNP-cell interactions and their biological consequences. We aim to understand the physicochemical impact of LNPs on cell membranes (1-100nm scale) and connect these findings to standard toxicity measures. This research will reveal potential adverse LNP effects, crucial for both molecular biology and clinical applications.Where to apply E-mail[email protected]RequirementsResearch Field Chemistry Education Level PhD or equivalentResearch Field Physics Education Level PhD or equivalentSkills/QualificationsThe responsibilities of the post-doctoral researcher will include:Experimental Design and Execution: designing and conducting experiments both in vitro (test tube) and in cell cultures, working with various laboratory techniques (confocal microscopy, fluorescence spectroscopy, biochemical assays, flow cytometry) and equipment.
- Data Analysis.
- Literature Review and Critical Analysis: staying up-to-date with the latest research in the field, comparing new findings with previous work, and contributing to the intellectual development of the project.
- Manuscript Preparation.
Specific Requirements1. PhD degree in chemical, physical or biological sciences, obtained in the year of employment in the project or within 7 years before 1 January of the year of employment in the project. For researchers with multiple PhDs, the date of the first PhD award is deemed the reference date. Extension might apply according to National Science Centre, Poland, rules.2. Additionally, the candidate for the postdoctoral position must meet the following condition:
- they did not have the principal investigator as their research supervisor or auxiliary supervisor of their PhD dissertation;
- their PhD degree has been awarded by another institution than the one planned to employ them at this post or they have completed a continuous and evidenced post-doctoral fellowship of at least 10 months in another institution than the host institution for the project and in another country than the one in which they have been conferred a PhD degree
3. Publication record and experience in research.4. Ability to work independently as well as in a group.5. Experience in at least two from the following techniques: cell culture, confocal microscopy, spectroscopy (FCS, FRET, FLIM) and/or flow cytometry.6. Ability to communicate fluently in English (written and spoken).7. Strong motivation to work and solving scientific problems, creativity, and analytical thinkingLanguages ENGLISH Level ExcellentResearch Field Chemistry » Physical chemistry Years of Research Experience 4 – 10Research Field Physics » Biophysics Years of Research Experience 4 – 10Additional InformationBenefitsWe offer a post-doctoral position (full-time employment) in the Institute of Physical Chemistry PAS with a gross salary of Around 9 650 PLN gross per month financed from the NCN OPUS 27 Project no 2024/53/B/ST4/01213 Entitled “Effect of lipid nanoparticles on the nanostructure of cell cytoplasm” 100% of the work time of Postdoc will be devoted to the realization of the proposed project. The offer is for 24 months with a possible extension The selected candidate will gain valuable new knowledge and techniques to enhance their skill set. This project encompasses biophysics, nanotechnology, cell biology, and physical chemistry, offering a learning opportunity for individuals from diverse backgrounds. We intend to publish the findings in prestigious high-impact journals. The successful candidate will be eligible for all programs at the IPC PAS, including the IPC PAS Young Scientists competition and the IPC PAS Young Scientists Mobility competition. Institute provides an opportunity to participate in ERASMUS+ programme.Eligibility criteriaThe successful candidate for the postdoctoral position shall, for the full term of their employment within the project, be obligated to maintain compliance with the following conditions: – at the time of receiving remuneration, they will not be receiving any other remuneration paid from the funds granted to research projects under NCN calls under the heading of direct costs – in the period of receiving the remuneration they will be receiving no remuneration from another employer pursuant to an employment contract, including an employer with registered office outside of Poland. – when the remuneration is paid, they will be receiving no pension under the social insurance scheme A post-doc type post is a full-time post, scheduled by the project’s principal investigator for a person who has been conferred a PhD degree in the year of employment in the project or within 7 years before 1 January of the year of employment in the project. For researchers with multiple PhDs, the date of the first PhD award is deemed the reference date. This period may be extended by a time of long-term (in excess of 90 days) documented sick leaves or rehabilitation leaves granted on account of being unfit to work. In addition, the period may be extended by the number of months of a childcare leave granted pursuant to the Labour Code and in the case of women, by 18 months for every child born or adopted, whichever manner of accounting for career breaks is preferable.Selection processThe Recruitment Commission will take into account the following criteria:– competencies for specific tasks in the research project– knowledge in biophysics– previous scientific achievements -awards and distinctions resulting from the conducted researchRequired documents :
- employment application;
- professional curriculum vitae including a list of scientific achievements (publications, patents, conference presentations and research projects); • PhD certificate or other document confirming PhD degree.
- The application deadline is on the 05.05.2025 , 12:00 noon
Applications should be sent to . IMPORTANT! email subject: “Recruitment no 12/2025 ” (emails without this number will not be considered)
- Top candidates can be invited for an online or in-person interview . We reserve the right to contact and reply to only selected candidates.
- The position will be offered to the person with the highest evaluation by the Recruitment Committee.
- The results of the recruitment are planned to be announced on the 02.06.2025.
- Employment will take place in accordance with the provisions of the competition documentation of the National Science Center (NSC) for the OPUS 27 call ( ) and Employment policy of the Institute of Physical Chemistry PAS .
- The incomplete applications will not be considered
- The results of the competition are made public.
- Candidates who have been issued a negative opinion by the Competition Committee or candidates not selected for employment have the right to appeal against the results of the evaluation. The appeal shall be lodged with the Director of the Institute within 7 days from the date of receipt of the appropriate information. The decision of the Director of the Institute shall be final.
Appeals should be sent to the following email address: .If the top candidate does not sign the contract due to the resignation, we reserve the right to choose the next candidate from the ranking list.Additional commentsBy submitting the application you consent to the processing of your personal data in the recruitment process. The controller of your personal data is the Institute of Physical Chemistry of the Polish Academy of Sciences with its registered office in Warsaw, NIP: 5250008755 (the “Institute”). The Institute will process your data for the purpose of carrying out scientific and research activities, providing services and contact with the Institute, on the basis of a contract (in connection with the performance of the contract or in order to take action on your request before the contract is concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal provisions (Article 6, paragraph 1, letter c) of the GDPR) – depending on the circumstances. You have the right to: request access to your data, receive a copy of it; rectify (correct) it; delete it; limit its processing; transfer it; lodge a complaint to the supervisory body; withdraw your consent for processing at any time (withdrawal of consent does not affect the lawfulness of the processing carried out prior to its withdrawal) or to lodge an objection to data processing. More information is available on the Institute’s website.Procedure for Reporting Internal Violations of the Law and Subsequent Actions together with Protection of Whistleblowers at the Institute of Physical Chemistry of the PAS with its registered address in WarsawWork Location(s)Number of offers available 1 Company/Institute Institute of Physical Chemistry Polish Academy of Sciences Country Poland City Warsaw Postal Code 01-224 Street Kasprzaka 44/52 GeofieldContact CityWarsaw WebsiteStreetWarsaw, Kasprzaka 44/52 Postal CodePL-01-224 E-Mail[email protected] Phone+48 22 343 3127STATUS: EXPIREDShare this page
Expected salary
Location
Warszawa, mazowieckie
Job date
Wed, 09 Apr 2025 03:56:51 GMT
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