Postdoctoral Fellow – Chudnovskiy Lab

Job title:

Postdoctoral Fellow – Chudnovskiy Lab

Company:

Francis Crick Institute

Job description

Salary for this Role:From £43,210, subject to skills and experienceJob Title:Postdoctoral Fellow – Chudnovskiy LabReports to: Aleksey ChudnovskiyClosing Date: 12/May/2024 23.59 GMTJob Description:Postdoctoral Fellow – A. Chudnovskiy lab.Reporting to: Aleksey Chudnovskiy, Group LeaderContact term: This is a full time 4-year position on Crick terms and conditions of employment.The Research GroupThe laboratory of Tumour-Immune Communication has been established in early 2024. We study bidirectional interactions between cancer cells and the host immune system using synthetic and molecular biology, genetics, and immunology. This research delineates how interaction dynamics between tumour cells and immune cells influence each other, contributing to our understanding of tumour progression and antitumour immune response.The ProjectThis project is designed to understand the interactions between tumour cells and immune cells utilising a variety of tumour cell lines and genetic models, with a primary but not exclusive focus on lung cancer and lung metastases. Our laboratory is equipped to track tumour-immune interactions at the single cell level. The LIPSTIC system—Labeling Immune Partnerships by SorTagging Intercellular Contacts—is used to unravel the cellular communication within the tumour microenvironment, concentrating on the interactions between tumour cells and immune cells, as well as between different antigen-presenting cells and T cells. The postdoctoral researcher will employ advanced genetic and molecular biology techniques as well as a lot of scRNA-seq to investigate the principles that govern the dynamics of tumour-immune interactions, aiming to apply this understanding to the development of cancer treatments. The work will involve the study of a wide range of tumour models, with an emphasis on lung cancer and other cancers that metastasise to the lung. The initial phase of the project will characterise the nature of tumour-immune interactions during steady-state tumour growth and after therapeutic interventions. In the later stages, the project is likely to evolve into a detailed mechanistic study of the interactions between specific immune cell populations and tumour cells. The ultimate goal is to utilise the findings from these studies to enhance therapeutic approaches for cancer.The postholder will be responsible for:Performing initial characterization of tumor-immune interactions at a single cell level using LIPSTIC and other cell-cell interaction tracing techniques.Understanding molecular mechanisms that drive tumor-immune interactions.Manipulating tumor-immune interactions to enhance antitumor immunity.Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.Key experience and competenciesThe post holder should embody and demonstrate our core Crick values:Bold; Open; CollegialEssentialPhD in immunology, cancer biology, molecular or cellular biology or in the final stages of PhD submissionGood knowledge and experience in immunology and/or tumor biology and/or molecular or cellular biologyTechnical expertise in basic immunological and/or molecular and/or cellular biology techniques.Track record of writing papers as evidenced by publications or submitted manuscripts in referred journalsEvidence of data presentation at scientific meetingsDesirableExperience in research with mouse tumour models cell lines or genetic tumour modelsGood understanding of innate and adaptive immunityExperience in flow cytometry, single cell sequencing, Cas9 based genetic screens, single cell RNA-seq data analysis using R or PythonAbout UsAt the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.If you are interested in applying for this role, please apply via our .All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.If you require a visa to work in the UK we will help support your application should you be successfulEquality, Diversity & InclusionWe welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:Find out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

Location

London

Job date

Fri, 15 Mar 2024 04:36:07 GMT

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