Postdoctoral Researcher (Clinical and translational bioinformatics)

Job title:

Postdoctoral Researcher (Clinical and translational bioinformatics)

Company:

Vall d’Hebron Research Institute

Job description

VHIR offers a position for a Postdoctoral researcher in the development of Interpretable Pathogenicity Predictors and cellular AI models for Breast Cancer within Clinical and Translational Bioinformatics Group to participate in the project: Hacia una mejor aplicabilidad de la Inteligencia Artificial en Medicina Genómica: Integrando capacidad predictiva e interpretabilidad en una nueva generación de herramientas para la anotación de variantes de proteínas, file number: PID2022-142753OB-I00, financed by Ministerio de Ciencia, Innovación y Universidades.Education and qualifications:Required:

• PhD Degree in Biotechnology, or closely related fields, centered in a fully Bioinformatics project
• Master’s in Bioinformatics
• Bachelor’s degree in Sciences, Biochemistry or Genetics
• Fluency in Catalan, Spanish and English

Experience and knowledge:Required:

• At least 4 to 5 years of experience working in the development of predictors of the impact of protein sequence variants on protein function (continuous prediction), in BRCA1/2 proteins
• Experience in the development of online tools for the graphical analysis of binary pathogenicity predictions
• Experience in the development of cost models (with reject and no reject options) for binary pathogenicity predictors
• High-level expertise in Python programming and Python data analysis tools (Jupyter Notebook, Biopython, Tabix, Pandas, Numpy, Scipy, Scikit-Learn, etc.)
• Experience in bioinformatics analysis for biomedical/clinical applications of the following genomics experiments: Whole Exome Sequencing (WES), RNA-seq, scRNA-seq, ChIP-seq, microRNA-seq, and Hi-C (TAD location and analysis)
• Experience in web development (Django, HTML5, CSS3, JavaScript, etc.)
• Experience in system administration of Mac and Ubuntu computers, NAS storage, etc.

Desired:

• Experience and good knowledge of standard bioinformatics tools (sequence comparison, multiple sequence alignments, structure analysis, etc.)

Main responsibilities and duties:

• Develop AI/ML models for identifying pathogenic and benign variants, and processing single cell experiments looking for the cell of origin in Breast Cancer tumors.
• Take the lead in our research in the development of interpretable pathogenicity predictors based on RiskSLIM, FasterRisk, and GODST technology.
• Take the lead in our research in the development and web programming of our graphical representations for the interpretation of pathogenicity predictions.
• Active implementation and refinement, whenever required, of the cost models of our group.
• Manage our collaboration with the Oncogenetics group (VHIO) and the Immunogenetics Area (VHIR) at the Vall d’Hebron Hospital.
• Any other work required for ongoing or new research: analysis of epigenetic/epigenomics data, of RNAseq experiments (bulk and single-cell), of WES, etc.; structural analyses of protein systems; etc.
• All aspects related to the management of our computer systems, from backups to updates, particularly those associated to the research project.

Labour conditions:

• Full-time position: 40h/week
• Starting date: April 1st, 2025
• Gross annual salary: Remuneration will depend on experience and skills
• Contract: Technical and scientific activities contract linked to the project activities

What can we offer?

• Incorporation to Vall d’Hebron Research Institute (VHIR), a public sector institution that promotes and develops the biomedical research, innovation and teaching at Vall d’Hebron University Hospital (HUVH), the biggest hospital of Barcelona and the largest of Catalan Institute of Health (ICS).
• A scientific environment of excellence, highly dynamic, where high-end biomedical projects are continuously developed.
• Continuous learning and a wide range of responsibilities within a stimulating work environment.
• Individual training opportunities.
• Flexible working hours.
• 23 days of holidays + 9 personal days.
• Flexible Remuneration Program (including dining checks, health insurance, transportation and more)
• Corporate Benefits: platform through which you can obtain significant discounts on travel, culture, technology, gastronomy, sports… among many others.
• Healthy Offering: choose from a variety of wellbeing focused activities to be the healthiest you.

Deadline to apply: 27-03-2025
VHIR embraces Equality and Diversity. As reflected in our values we work toward ensuring inclusion and equal opportunity in recruitment, hiring, training, and management for all staff within the organization, regardless of gender, civil status, family status, sexual orientation, gender identity and expression, religion, age, functional diversity or ethnicity.

Expected salary

Location

Barcelona

Job date

Sun, 16 Mar 2025 01:23:12 GMT

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