Senior Scientist, Discovery Genomics

Job title:

Senior Scientist, Discovery Genomics

Company:

GlaxoSmithKline

Job description

Are you a passionate and skilled genomics scientist ready to make an impact in the world of drug discovery? Here’s your chance to be at the heart of groundbreaking research and pioneering discoveries that shape the future of medicine in the Discovery Genomics group within the Target Discovery department at GSK.Why Join Us:

• Cutting-Edge Research: You will be instrumental in shaping experiments and providing critical datasets for in-house CRISPR, chemical and large molecule screening. Your contributions will directly drive target discovery and validation at scale, pushing the boundaries of what’s possible in genomics.
• Collaborative Environment: You’ll have the opportunity to support diverse projects across the pipeline, working hand-in-hand with colleagues to generate evidence that addresses key questions for GSK’s assets and disease focus areas. Our team spans three GSK sites in Stevenage (UK), Heidelberg (Germany) and Philadelphia (USA), with opportunities to work on multi-Omics projects that span multiple locations.
• Impactful Work: Your efforts will directly impact patient outcomes. By leveraging your expertise in genomics assays, you’ll play a pivotal role in advancing our understanding of diseases and developing novel therapeutic solutions.

What You’ll Do:

• Innovative Research: Implement a wide range of genomics assays, from RNA-seq and scRNA-seq techniques to epigenetics assays and next-generation sequencing. Your role will involve not only utilizing existing techniques but also pioneering new approaches to enhance our discovery methodologies.
• Collaborative Partnerships: Navigate a highly matrixed organization, collaborating closely with key stakeholders in computational biology, AIML, and biology research units. Together, we’ll work towards common goals and make impactful decisions that benefit patients worldwide.
• Continuous Learning: Stay at the forefront of the field by scoping out new techniques and technologies that could revolutionize our discovery approaches. Whether it’s experimental, in silico, or automation technologies, you’ll have scope to explore and implement the latest advancements in genomics research which benefit our work.

What You Bring:

• Passion and Drive: A relentless passion for genomics research and a drive to make a meaningful difference in the lives of patients.
• Expertise: A solid foundation in genomics assays, coupled with hands-on experience in techniques such as RNA-seq, single-cell sequencing, and epigenetics assays.
• Collaborative Spirit: An ability to thrive in a collaborative environment, working seamlessly with colleagues from diverse backgrounds to achieve common objectives.
• Innovation: A creative mindset and a knack for exploring new techniques and technologies to push the boundaries of discovery.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageKey Responsibilities include, but are not limited to:

• Planning and executing data generating phases of screens where you will be designing and executing single cell and bulk transcriptomics workflows which are key parts of our discovery screening projects.
• Maintain and improve critical lab workflows and equipment in collaboration with automation experts and vendors.
• As part of the Discovery Genomics group, other responsibilities will include assisting with sequencing workflows, and data QC and analysis where appropriate.
• You will demonstrate the ability to work effectively in multidisciplinary teams and will display excellent interpersonal and communication skills, interacting with scientists and external collaborators at all levels.
• You will be expected to maintain knowledge of current scientific literature relevant to the role.
• A proactive attitude, excellent organisational skills and good record keeping are essential. You will be expected to present your results/data at both internal and external meetings.

Basic QualificationsWe are looking for professionals with these required skills to achieve our goals:

• PhD or equivalent laboratory experience in molecular and cellular biology with significant experience in genomics workflows.
• Demonstrated experience in designing experiments using bulk RNA-seq and single cell RNA-seq and related technologies.
• Sound knowledge of molecular biology techniques including: qRT-PCR, NGS library preparation and QC.
• Demonstrated ability to design experiments, solve problems independently, troubleshoot protocols and implement novel protocols.
• Proven ability to work independently and as part of a multidisciplinary team.
• Strong organisational and communication skills and a demonstrated ability to liaise with scientists at all levels of seniority.

Preferred QualificationsIf you have the following characteristics, it would be a plus:

• Experience in applying computational analysis methodologies for genomics data, including data QC, pre-processing and primary analysis, in particular for RNA-seq or single cell RNA-seq.
• Understanding of focused and/or genome-wide pooled CRISPR screens.
• Understanding of the drug discovery process and how genomics can be used to support target discovery and assets in later stages of the pipeline.
• Working knowledge of immunology or experience with primary human cell based projects.
• Demonstrated experience in working on projects using complex in vitro models, such as primary (immune) cells, iPSCs or organoids/spheroids.

Closing Date for Applications – 24th May 2024 (COB)Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. 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Expected salary

Location

Stevenage, Hertfordshire

Job date

Sun, 12 May 2024 06:32:12 GMT

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