Translation regulation and hematopoise

Job title:

Translation regulation and hematopoise

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Job description

Offer DescriptionWe seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation and mechanisms during megakaryopoiesis. The candidate needs to hold a PhD with good record of publications,preferentially with no more than 2 years after getting PhD. Candidate needs to have a strong background in molecular biology and biochemistry with knowledge in cell culture, western blot, immune-fluorescence andRNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc willhave access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups and will receive mentoring for career development.Funding category: Financement public/privéANRPHD Country: FranceWhere to apply WebsiteRequirementsSpecific RequirementsBackground: Over the past decade, genetic lesions that cause ribosome dysfunctions have been identified in
both congenital and acquired human disorders. These ribosome modifications can directly impact translation
levels and quality in cells. Very recent data underline that ribosome biogenesis is involved in mediating the
transition between proliferation and differentiation of erythroid progenitors. The functional consequences of
translation and protein synthesis regulation on megakaryopoiesis remains largely unexplored. Our preliminary
data suggest that translation regulation and modification of the ribosomal protein RPS6 might have a critical
role in the megakaryopoiesis and platelet formation.
The goal of the postdoctoral project is to determine the role of the translation regulation during
megakaryopoiesis and to explore the potential roles of the ribosomal protein RPS6 in this process.
Qualification: We seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation
and mechanisms during megakaryopoiesis. The candidate needs to hold a PhD with good record of publications,
preferentially with no more than 2 years after getting PhD. Candidate needs to have a strong background in
molecular biology and biochemistry with knowledge in cell culture, western blot, immune-fluorescence and
RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in
both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc will
have access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups
and will receive mentoring for career development.Additional InformationWork Location(s)Number of offers available 1 Company/Institute GIN Grenoble Institut des Neurosciences Country France City Grenoble GeofieldContact WebsiteSTATUS: EXPIREDShare this page

Expected salary

Location

Grenoble, Isère

Job date

Fri, 06 Jun 2025 04:11:11 GMT

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